自引率: 9.6%
被引量: 2516
通过率: 暂无数据
审稿周期: 1
版面费用: 暂无数据
国人发稿量: 4
投稿须知/期刊简介:
Biogerontology has now developed a solid scientific base with respect to the understanding of the phenomenon of aging. A spectrum of new and innovative strategies and approaches are being increasingly applied to modulate the process of aging at the level of cells tissues organs and organisms. Biogerontology represents this step in research which aims primarily at achieving healthy old age accompanied by improved longevity. The focus is on attempts to understand prevent cure or minimize age-related impairments. The science of healthy old age requires its own platform to bring forward new ideas and to encourage the scientific publication of innovative and bold experimental manipulations in this regard. Biogerontology therefore provides a peer-reviewed forum for publishing original research data new ideas and discussions about: Modulating the aging process by physical chemical and biological means including transgenic and knockout organisms; Cell culture systems to develop new approaches and health care products for maintaining and/or recovering the lost biochemical functions; Immunology autoimmunity and infection in aging; Vertebrates invertebrates micro-organisms and plants for experimental studies on genetic determinants of aging and longevity; Biodemography and theoretical models linking aging and survival kinetics. Biogerontology will publish: original research reports; reviews hypotheses new methods and interviews; special issues on specific topics relating to aging health and longevity.
期刊描述简介:
Biogerontology has now developed a solid scientific base with respect to the understanding of the phenomenon of aging. A spectrum of new and innovative strategies and approaches are being increasingly applied to modulate the process of aging at the level of cells tissues organs and organisms. Biogerontology represents this step in research which aims primarily at achieving healthy old age accompanied by improved longevity. The focus is on attempts to understand prevent cure or minimize age-related impairments. The science of healthy old age requires its own platform to bring forward new ideas and to encourage the scientific publication of innovative and bold experimental manipulations in this regard. Biogerontology therefore provides a peer-reviewed forum for publishing original research data new ideas and discussions about: Modulating the aging process by physical chemical and biological means including transgenic and knockout organisms; Cell culture systems to develop new approaches and health care products for maintaining and/or recovering the lost biochemical functions; Immunology autoimmunity and infection in aging; Vertebrates invertebrates micro-organisms and plants for experimental studies on genetic determinants of aging and longevity; Biodemography and theoretical models linking aging and survival kinetics. Biogerontology will publish: original research reports; reviews hypotheses new methods and interviews; special issues on specific topics relating to aging health and longevity.
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Dysbiosis and fecal microbiota transplant: Contemplating progress in health, neurodegeneration and longevity.
被引量：- 发表：1970
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Screening the active ingredients of plants via molecular docking technology and evaluating their ability to reduce skin photoaging.
被引量：- 发表：1970
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Chrysin mitigates neuronal apoptosis and impaired hippocampal neurogenesis in male rats subjected to D-galactose-induced brain aging.
被引量：- 发表：1970
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The impact of mosaic loss of the Y chromosome (mLOY) in men of advanced age.
The Y chromosome has long been considered to be a "genetic wasteland" harboring only few genes essentially involved in male sex development and spermatogenesis. However, the discovery of mosaic loss of the Y chromosome (mLOY) in older men has led to revisiting of the potential impact of the Y chromosome on health and the pathophysiological processes of multiple diseases such as cancer, Alzheimer's disease and cardiovascular disease. Hence, developing more sensitive techniques for the detection of mLOY has become an emergent concern. In this article, we present a comprehensive review of the literature regarding mLOY. Additionally, we discuss the emerging discoveries concerning mLOY as well as the underlying mechanisms promoting disease in men of advanced age.
被引量：- 发表：1970
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Caloric restriction mimetics improve gut microbiota: a promising neurotherapeutics approach for managing age-related neurodegenerative disorders.
The gut microbiota (GM) produces various molecules that regulate the physiological functionality of the brain through the gut-brain axis (GBA). Studies suggest that alteration in GBA may lead to the onset and progression of various neurological dysfunctions. Moreover, aging is one of the prominent causes that contribute to the alteration of GBA. With age, GM undergoes a shift in population size and species of microflora leading to changes in their secreted metabolites. These changes also hamper communications among the HPA (hypothalamic-pituitary-adrenal), ENS (enteric nervous system), and ANS (autonomic nervous system). A therapeutic intervention that has recently gained attention in improving health and maintaining communication between the gut and the brain is calorie restriction (CR), which also plays a critical role in autophagy and neurogenesis processes. However, its strict regime and lifelong commitment pose challenges. The need is to produce similar beneficial effects of CR without having its rigorous compliance. This led to an exploration of calorie restriction mimetics (CRMs) which could mimic CR's functions without limiting diet, providing long-term health benefits. CRMs ensure the efficient functioning of the GBA through gut bacteria and their metabolites i.e., short-chain fatty acids, bile acids, and neurotransmitters. This is particularly beneficial for elderly individuals, as the GM deteriorates with age and the body's ability to digest the toxic accumulates declines. In this review, we have explored the beneficial effect of CRMs in extending lifespan by enhancing the beneficial bacteria and their effects on metabolite production, physiological conditions, and neurological dysfunctions including neurodegenerative disorders.
被引量：- 发表：1970
