自引率: 5.8%
被引量: 3425
通过率: 暂无数据
审稿周期: 3
版面费用: 暂无数据
国人发稿量: 54
投稿须知/期刊简介:
Biomedical Microdevices is an interdisciplinary periodical devoted to all aspects of research in the diagnostic and therapeutic applications of Micro-Electro-Mechanical Systems (MEMS) microfabrication and nanotechnology. General subjects of interest include the design characterization testing modeling and clinical validation of microfabricated systems and their integration on-chip and in larger functional units. The specific interests of the Journal include systems for neural stimulation and recording bioseparation technologies such as nanofilters and electrophoretic equipment miniaturized analytic and DNA identification systems biosensors and microtechnologies for cell and tissue research tissue engineering cell transplantation and the controlled release of drugs and therapeutic proteins. Contributions reporting on fundamental and applied investigations of the material science biochemistry and physics of biomedical microdevices are encouraged. A non-exhaustive list of fields of interest includes: biochemical modification with reference to non-specific protein adsorption and the active immobilization and patterning of proteins on microfabricated surfaces; the dynamics of fluids in micro-and-nano-fabricated channels; the electromechanical and structural response of microfabricated systems; the interactions of microdevices with cells and tissues including biocompatibility and biodegradation studies; the variation of the characteristics of the systems as function of the microfabrication parameters.
期刊描述简介:
Biomedical Microdevices covers research in the diagnostic and therapeutic applications of Micro-Electro-Mechanical Systems, microfabrication, and nanotechnology. Topics include design, characterization, testing, modeling and clinical validation of microfabricated systems, and their integration on-chip and in larger functional units. The interests of the journal include systems for neural stimulation and recording; bioseparation technologies such as nanofilters and electrophoretic equipment; miniaturized analytic and DNA identification systems; biosensors; microtechnologies for cell and tissue research; tissue engineering; cell transplantation and the controlled release of drugs and therapeutic proteins. Coverage extends to biochemical modification and non-specific protein adsorption; fluid dynamics in micro- and nano-fabricated channels; electromechanical and structural response of microfabricated systems; interactions of microdevices with cells and tissues, including biocompatibility and biodegradation; and more.
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Panoramic review on polymeric microneedle arrays for clinical applications.
被引量：- 发表：1970
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Construction of a pumpless gravity-driven vascularized Skin-on-a-Chip for the study of hepatocytotoxicity in percutaneous exposure to exogenous chemicals.
被引量：- 发表：1970
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Ultrasound-assisted water oxidation: unveiling the role of piezoelectric metal-oxide sonocatalysts for cancer treatment.
Ultrasound radiation has been widely used in biomedical application for both diagnosis and therapy. Metal oxides nanoparticles (NPs), like ZnO or TiO2 NPs, have been widely demonstrated to act as excellent sonocatalysts and significantly enhance cavitation at their surface, making them optimal for sonodynamic cancer therapy. These NPs often possess semiconductive and piezoelectric properties that contribute to the complex phenomena occurring at the water-oxide interface during sonostimulation. Despite the great potential in applied sonocatalysis and water splitting, the complex mechanism that governs the phenomenon is still a research subject. This work investigates the role of piezoelectric ZnO micro- and nano-particles in ultrasound-assisted water oxidation. Three metal oxides presenting fundamental electronic and mechanical differences are evaluated in terms of ultrasound-triggered reactive oxygen species generation in aqueous media: electromechanically inert SiO2 NPs, semiconducting TiO2 NPs, piezoelectric and semiconducting ZnO micro- and nanoparticles with different surface areas and sizes. The presence of silver ions in the aqueous solution was further considered to impart a potential electron scavenging effects and better evaluate the oxygen generation performances of the different structures. Following sonoirradiation, the particles are optically and chemically analyzed to study the effect of sonostimulation at their surface. The production of gaseous molecular oxygen is measured, revealing the potential of piezoelectric particles to generate oxygen under hypoxic conditions typical of some cancer environments. Finally, the best candidates, i.e. ZnO nano and micro particles, were tested on osteosarcoma and glioblastoma cell lines to demonstrate their potential for cancer treatment.
被引量：- 发表：1970
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Multiplex antibiotic susceptibility testing of urinary tract infections using an electrochemical lab-on-a-chip.
Urinary tract infections (UTIs) represent the most prevalent type of outpatient infection, with significant adverse health and economic burdens. Current culture-based antibiotic susceptibility testing can take up to 72 h resulting in ineffective prescription of broad-spectrum antibiotics, poor clinical outcomes and development of further antibiotic resistance. We report an electrochemical lab-on-a-chip (LOC) for testing samples against seven clinically-relevant antibiotics. The LOC contained eight chambers, each housing an antibiotic-loaded hydrogel (cephalexin, ceftriaxone, colistin, gentamicin, piperacillin, trimethoprim, vancomycin) or antibiotic-free control, alongside a resazurin bulk-modified screen-printed electrode for electrochemical detection of metabolically active bacteria using differential pulse voltammetry. Antibiotic susceptibility in simulated UTI samples or donated human urine with either Escherichia coli or Klebsiella pneumoniae could be established within 85 min. Incorporating electrochemical detection onto a LOC provides an inexpensive, simple method for the sensitive determination of antibiotic susceptibility that is significantly faster than using a culture-based approach.
被引量：- 发表：1970
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A dynamic flow fetal membrane organ-on-a-chip system for modeling the effects of amniotic fluid motion.
被引量：- 发表：1970
