自引率: 2.5%
被引量: 7738
通过率: 暂无数据
审稿周期: 6
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国人发稿量: 14
投稿须知/期刊简介:
Published monthly by Blackwell Science on behalf of: The Belgian Society of Tropical Medicine Prince Leopold Institute of Tropical Medicine Bernhard-Nocht-Institute für Tropenmedizin Foundation for Tropical and Geographical Medicine London School of Hygiene and Tropical Medicine Swiss Tropical Institute. Tropical Medicine and International Health is the successor to, and combines and integrates the Annales de la Societe Belge de Medecine Tropicale, the Journal of Tropical Medicine and Hygiene, Tropical and Geographical Medicine (incorporating Acta Leidensia) and Tropical Medicine and Parasitology.
期刊描述简介:
Published monthly by Blackwell Science on behalf of: The Belgian Society of Tropical Medicine Prince Leopold Institute of Tropical Medicine Bernhard-Nocht-Institute für Tropenmedizin Foundation for Tropical and Geographical Medicine London School of Hygiene and Tropical Medicine Swiss Tropical Institute. Tropical Medicine and International Health is the successor to, and combines and integrates the Annales de la Societe Belge de Medecine Tropicale, the Journal of Tropical Medicine and Hygiene, Tropical and Geographical Medicine (incorporating Acta Leidensia) and Tropical Medicine and Parasitology.
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Patterns of house infestation dynamics by non-domiciliated Triatoma dimidiata reveal a spatial gradient of infestation in rural villages and potential insect manipulation by Trypanosoma cruzi.
Chagas disease is a major vector-borne parasitic disease in Latin America, primarily transmitted to humans by triatomine vectors. Non-domiciliated triatomine species such as Triatoma dimidiata in the Yucatan peninsula, Mexico, can transiently invade houses and are emerging as a major challenge to control Trypanosoma cruzi transmission to humans. We analyzed the spatio-temporal spreading of house infestation by T. dimidiata in four rural villages. Triatomines were collected in four rural villages over a 2 years period, and the spatio-temporal patterns of infestation were analyzed. Triatomines were consistently more abundant at the periphery of villages than in centers, indicating a much higher risk of T. cruzi transmission at the periphery. Male T. dimidiata were found further in the center of the village, while females remained closer to the periphery, suggesting differential dispersal capabilities between sexes, although the timing of dispersal appeared identical. Surprisingly, infected females were consistently collected in houses much further from the surrounding bushes than non-infected females, while the distribution of males was unaffected by their T. cruzi infection status, suggesting an increased dispersal capability in infected females. The spatial structure of infestation should be taken into account for the prioritization of vector control activities within villages, and spatially targeted interventions may be explored. A potential vector manipulation by T. cruzi, observed for the first time in triatomines, may favor parasite transmission to new hosts.
被引量：31 发表：1970
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Chromosomal variation and genome size support existence of cryptic species of Triatoma dimidiata with different epidemiological importance as Chagas disease vectors.
The wide geographical distribution of Triatoma dimidiata, one of the three major vectors of Chagas disease, ranges from Mexico to northern Peru. Since this species occupies a great diversity of artificial and natural ecotopes, its eradication is extremely difficult. In order to assist control efforts, we used chromosome analyses and DNA amount as taxonomic markers to study genetic variability in populations of T. dimidiata from Mexico, Guatemala, El Salvador and Colombia. We differentiated three groups or cytotypes defined by characteristic chromosome C-banding patterns and genome size measured by flow cytometry. The three cytotypes are restricted to different geographic locations. Cytotype 1 occurs in Mexico (excluding Yucatán), Guatemala (excluding Petén), El Salvador and Colombia. Cytotype 2 occurs in Yucatán and cytotype 3 occurs in Petén. Cytotype 1, commonly associated with domestic and peridomestic environments but also inhabiting sylvatic ecotopes, is the most widespread and with major epidemiological significance. In contrast, the Yucatán cytotype inhabits wild ecotopes but increasingly enters houses, while the Petén cytotype appears exclusively sylvatic. We suggest that these cytotypes represent cryptic species of T. dimidiata with different epidemiological relevance as Chagas disease vectors. Poor ability to colonize human dwellings, together with their restricted geographic distribution, indicate that the Yucatán and Petén putative species probably have much less epidemiological significance than cytotype 1. Thus, the genetic markers we describe are powerful tools to differentiate cryptic species in T. dimidiata with different epidemiological significance, contributing to planning the most effective control measures.
被引量：22 发表：2006
