自引率: 30.1%
被引量: 5205
通过率: 暂无数据
审稿周期: 3
版面费用: 暂无数据
国人发稿量: 4
投稿须知/期刊简介:
Providing an international forum for communicating the latest findings and state-of-the-art reviews on the burgeoning field of cardiovascular magnetic resonance (CMR) imaging and spectroscopy, the newly launched Journal of Cardiovascular Magnetic Resonance (JCMR) fills a critical gap in the science and practice of cardiology and related disciplines—facilitating the understanding and applications of CMR. Improve diagnostic capabilities, identify diseases more accurately, and assess the efficacy of therapeutic approaches! The first and only journal devoted exclusively to CMR, JCMR contains basic and clinical research articles, technical notes, review articles, and editorial commentary on the research, design, development, manufacture, and evaluation of magnetic resonance methods applied to the cardiovascular system. JCMR covers topics such as new applications of magnetic resonance to diagnose, risk stratify, and better characterize diseases affecting the cardiovascular system new methods to enhance acquisition and data analysis results of multicenter, or larger individual center, studies that provide insight into the utility of MR basic biological perceptions derived by MR methods Reporting new information and expertly reviewing all aspects of the field for the entire cardiac MR community, the JCMR serves as essential reading for: Clinicians, including adult and pediatric cardiologists, radiologists, cardiovascular surgeons, internists, primary care physicians, and family practitioners Technologists, including all professionals involved in the hands-on performance of MR tests Scientists, including vascular biologists, cardiac biochemists, NMR spectroscopists, imaging physicists, and biomedical engineers Product Manufacturers, including pharmaceutical firms, imaging system designers and manufacturers, NMR spectroscopy system manufacturers, and contrast agents companies.
期刊描述简介:
Providing an international forum for communicating the latest findings and state-of-the-art reviews on the burgeoning field of cardiovascular magnetic resonance (CMR) imaging and spectroscopy, the newly launched Journal of Cardiovascular Magnetic Resonance (JCMR) fills a critical gap in the science and practice of cardiology and related disciplines—facilitating the understanding and applications of CMR. Improve diagnostic capabilities, identify diseases more accurately, and assess the efficacy of therapeutic approaches! The first and only journal devoted exclusively to CMR, JCMR contains basic and clinical research articles, technical notes, review articles, and editorial commentary on the research, design, development, manufacture, and evaluation of magnetic resonance methods applied to the cardiovascular system. JCMR covers topics such as new applications of magnetic resonance to diagnose, risk stratify, and better characterize diseases affecting the cardiovascular system new methods to enhance acquisition and data analysis results of multicenter, or larger individual center, studies that provide insight into the utility of MR basic biological perceptions derived by MR methods Reporting new information and expertly reviewing all aspects of the field for the entire cardiac MR community, the JCMR serves as essential reading for: Clinicians, including adult and pediatric cardiologists, radiologists, cardiovascular surgeons, internists, primary care physicians, and family practitioners Technologists, including all professionals involved in the hands-on performance of MR tests Scientists, including vascular biologists, cardiac biochemists, NMR spectroscopists, imaging physicists, and biomedical engineers Product Manufacturers, including pharmaceutical firms, imaging system designers and manufacturers, NMR spectroscopy system manufacturers, and contrast agents companies.
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Simultaneous non-contrast assessment of cardiac microstructure and perfusion in vivo in the human heart.
Intravoxel incoherent motion (IVIM) imaging can provide information on cardiac microstructure and microvascular perfusion from a single examination. However, the spin echo-based approaches typically used for cardiac IVIM suffer from low sensitivity to changes in perfusion. The aim of this work was to develop a stimulated-echo (STEAM)-based method for IVIM and diffusion tensor cardiovascular magnetic resonance to simultaneously provide biomarkers of microstructure and perfusion in vivo in the human heart. Here we introduce a novel STEAM-IVIM sequence incorporating phase cycling to obtain true non-diffusion weighted images (b = 0 s/mm2). STEAM-IVIM imaging was performed at 20 b-values (0 to 1000 s/mm2) to enable accurate estimation of the IVIM parameters, and with six diffusion encoding directions to enable reconstruction of the diffusion tensor. 20 healthy subjects (8 female, median age 31 years) were imaged on a clinical 3T system with STEAM-IVIM. A simulation study was performed to investigate the optimal fitting algorithms for the IVIM parameters, which was subsequently used to create pixel-wise IVIM parameter maps for the in vivo acquisitions. Good image quality across the myocardium was obtained for all b-values. Mean(±SD) IVIM parameter estimates were: diffusivity D = 0.83 ± 0.07 × 10-3 mm2/s, perfusion coefficient D* = 19.08 ± 6.48 × 10-3 mm2/s, perfusion fraction f = 19.72 ± 4.11%, and mean diffusion tensor parameters were: mean diffusivity = 0.88 ± 0.06 × 10-3 mm2/s, fractional anisotropy = 0.45 ± 0.04, absolute E2 angle = 55.29 ± 6.38º, helix angle gradient = -0.68 ± 0.18º/%. Phase-cycled STEAM-IVIM enables fitting of cardiac diffusion tensor and perfusion parameters in healthy subjects and shows promise for the simultaneous detection of microstructural aberration and perfusion abnormalities in the presence of cardiac disease without the need for exogenous contrast agents.
被引量：- 发表：1970
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Longitudinal changes in systemic right ventricular remodeling in adult patients with transposition of the great vessels as assessed by cardiovascular magnetic resonance imaging.
Systemic right ventricular (sRV) physiology occurs in patients with congenitally corrected transposition of the great arteries (ccTGA) and D-TGA post atrial switch repair, and the natural history is of progressive sRV dysfunction. No study has assessed longitudinal changes in sRV remodeling by serial cardiovascular magnetic resonance (CMR). Patients evaluated at two adult congenital heart disease centers and who underwent ≥2 CMR exams were studied. Indexed sRV end-diastolic volume (sRVEDVi), end-systolic volume (sRVESVi), and ejection fraction (sRVEF) were determined by a core laboratory. Concurrent echocardiograms were assessed for degree of systemic tricuspid regurgitation (sTR). Tricuspid valve events were defined as ≥moderate sTR, or interval tricuspid valve replacement (TVR). Generally, the earliest and most recent studies were compared. A subset of patients were followed with ≥moderate sTR, and then subsequently underwent interval TVR. For these patients, two study time intervals were defined to analyze the impact of each event independently. Sixty-seven patients were studied (33 ± 11 years, 48% [32/67] male, 33% [22/67] ccTGA), with 72 total time intervals studied (median interval 9.0 years [interquartile range 4.6-13.3]). There was a small increase in sRVEDVi over time (ΔsRVEDVi 5.5 ± 15.8 mL/m2, p < 0.001), but mean change in sRVEF was not significant (ΔsRVEF 0.1 ± 6.9%, p = 0.86); notably, confidence intervals (CI) were wide for both. ccTGA patients had a trend toward greater decrement in sRVEF (ΔsRVEF -1.7 ± 6.8 vs 1.3 ± 6.7%, p = 0.06). For each 25 mL/m2 increase in baseline sRVEDVi, there was a 1.8% decrease in sRVEF (95% CI -3.2% to -0.5%, p = 0.01). Patients without significant sTR had lesser deterioration in sRVEF compared to those with ≥moderate sTR or with interval TR intervention (ΔsRVEF 1.8 ± 6.9% vs -2.1 ± 6.6% and -2.6 ± 4.5, p < 0.05). Interval sRV conduction delay was associated with a trend toward greater decrements in sRVEF (ΔsRVEF -3.9 ± 6.3 vs 0.9 ± 6.8%, p = 0.07). Overall, underlying congenital anatomy, baseline sRVEDVi, advanced sTR or interval TVR, and sRV conduction delay explained only 16% of the variability in ΔsRVEF over time. Longitudinal changes in sRV remodeling were small, with great heterogeneity. Apparent risk factors in our study, namely underlying congenital anatomy, baseline sRVEDVi, TR events, and sRV conduction disease accounted for only 16% of the variability seen in the longitudinal change of sRVEF.
被引量：- 发表：1970
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Prognostic value of global coronary flow reserve before and after elective percutaneous coronary intervention in patients with chronic coronary syndrome.
Impaired global coronary flow reserve (G-CFR), evaluated through phase-contrast cine cardiovascular magnetic resonance (PC-CMR), has been linked to worse outcomes in patients with cardiovascular disease. This study aimed to investigate the prognostic value of G-CFR improvement, as evaluated using PC-CMR imaging pre- and post-percutaneous coronary intervention (PCI). In this single-center study, 320 patients with chronic coronary syndrome (CCS) who underwent pre- and post-PCI PC-CMR measurements were followed up to determine major adverse cardiac or cerebrovascular events (MACCE) predictors. MACCE was defined as a composite of cardiac death, nonfatal myocardial infarction, hospitalization due to heart failure, or ischemic stroke. The association between CMR parameters, including baseline data, G-CFR changes post-PCI, and MACCE, was investigated. G-CFR improvement was observed in 51.6% (165/320) patients, while MACCE occurred in 8.1% (26/320) during a median follow-up period of 2.5 years. G-CFR improvement was significantly associated with a lower pre-PCI G-CFR. The log-rank test revealed a significant association between patients without G-CFR improvement post-PCI and a poor prognosis. Patients with lower pre-PCI G-CFR and lack of G-CFR improvement exhibited the highest incidence of MACCE. The multivariable Cox proportional hazard model revealed that lack of G-CFR improvement was an independently significant MACCE predictor from pre-PCI G-CFR and SYNTAX (Synergy between PCI with Taxus and Cardiac Surgery) score. Besides the association between pre- and post-PCI lower G-CFR and worse prognosis, the presence or absence of G-CFR improvement post-PCI may provide novel insights into the prognosis following elective PCI in patients with CCS.
被引量：- 发表：1970
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Active left atrial ejection fraction as a non-invasive marker in pulmonary hypertension secondary to heart failure.
Patients with pulmonary hypertension (PH) secondary to left heart failure (HF) exhibit a complex pathophysiological profile and poor prognosis. Left atrial (LA) function is pivotal in the progression of this disease, yet its predictive significance remains exclusive. This study aimed to explore the predictive capability of LA metrics in this population and compare them with other common predictors. In this retrospective study, consecutive patients with PH secondary to HF who underwent cardiac magnetic resonance (CMR) imaging between December 2010 and December 2021 were enrolled. The composite endpoint was defined as all-cause death, heart-lung transplantation, or left ventricular assist device implantation. Survival analyses were performed using Kaplan-Meier curves and Cox regression analyses. A total of 174 patients with PH secondary to HF, with a mean age of 53.2 ± 14.9 years, including 90 men, were included in the final analysis. During a median follow-up of 31.9 months, 33.3% (58/174) of the patients with PH reached the endpoints. There was a fair correlation between active left atrial ejection fraction (LAEF) and pulmonary artery wedge pressure (r = -0.397, p = 0.044). Active LAEF had a strong correlation with oxygen consumption at anaerobic threshold (r = 0.769, p < 0.001) and peak oxygen consumption (r = 0.754, p < 0.001). Active LAEF demonstrated comparable prognostic performance to other variables measured by echocardiography or CMR. After adjusting for clinical variables and left ventricular ejection fraction, active LAEF was still an independent predictor for adverse events (C-statistic: 0.784). Subgroup analysis among HF patients with preserved ejection fraction demonstrated that those with active LAEF ≤8.6% had a 7.05-fold higher risk of experiencing the composite endpoint compared to those with active LAEF >8.6%. Although active LAEF does not demonstrate statistical improvement in outcome discrimination compared to established metrics, it may still merit consideration for assessing disease severity and prognosis in patients with PH secondary to HF. The integration of active LAEF and HF subtypes may stratify individuals at different levels of risk.
被引量：- 发表：1970
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Assessment of abnormal transvalvular flow and wall shear stress direction for pediatric/young adults with bicuspid aortic valve: A cross-sectional four-dimensional flow study.
Aortic dilation is seen in pediatric/young adult patients with bicuspid aortic valve (BAV), and hemodynamic markers to predict aortic dilation are necessary for monitoring. Although promising hemodynamic metrics, such as abnormal wall shear stress (WSS) magnitude, have been proposed for adult BAV patients using four-dimensional (4D) flow cardiovascular magnetic resonance, those for pediatric BAV patients have less frequently been reported, partly due to scarcity of data to define normal WSS range. To circumvent this challenge, this study aims to investigate if a recently proposed 4D flow-based hemodynamic measurement, abnormal flow directionality, is associated with aortic dilation in pediatric/young adult BAV patients. 4D flow scans for BAV patients (<20 years old) and age-matched controls were retrospectively enrolled. Static segmentation for the aorta and pulmonary arteries was obtained to quantify peak systolic hemodynamics and diameters in the proximal aorta. In addition to peak velocity, WSS, vorticity, helicity, and viscous energy loss, direction of aortic velocity and WSS in BAV patients were compared with that of control atlas using registration technique; angle differences of >60 deg and >120 deg were defined as moderately and severely abnormal, respectively. The association between the obtained metrics and normalized diameters (Z-scores) was evaluated at the sinotubular junction, mid-ascending aorta, and distal ascending aorta. Fifty-three BAV patients, including 18 with history of repaired aortic coarctation, and 17 controls were enrolled. Correlation between moderately abnormal velocity/WSS direction and aortic Z-scores was moderate to strong at the sinotubular junction and mid-ascending aorta (R = 0.62-0.81; p < 0.001) while conventional measurements exhibited weaker correlation (|R| = 0.003-0.47, p = 0.009-0.99) in all subdomains. Multivariable regression analysis found moderately abnormal velocity direction and existence of aortic regurgitation (only for isolated BAV group) were independently associated with mid-ascending aortic Z-scores. Abnormal velocity and WSS directionality in the proximal aorta were strongly associated with aortic Z-scores in pediatric/young adult BAV patients.
被引量：- 发表：1970
