自引率: 0.8%
被引量: 85220
通过率: 暂无数据
审稿周期: 2.14
版面费用: 暂无数据
国人发稿量: 18
投稿须知/期刊简介:
The journal publishes original research in all disciplines of biomedical science, according to editorial assessment of a paper's potential interest, impact, and implications for clinical medicine and the biomedical community. The journal favours submissions that represent a conceptual advance or an original approach to understanding the molecular basis of pathogenesis and therapy.
期刊描述简介:
The journal publishes original research in all disciplines of biomedical science, according to editorial assessment of a paper's potential interest, impact, and implications for clinical medicine and the biomedical community. The journal favours submissions that represent a conceptual advance or an original approach to understanding the molecular basis of pathogenesis and therapy.
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Cell identification and isolation on the basis of cytokine secretion: a novel tool for investigating immune responses.
被引量：8 发表：2001
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ORP150 protects against hypoxia/ischemia-induced neuronal death.
:Oxygen-regulated protein 150 kD (ORP150) is a novel endoplasmic-reticulum-associated chaperone induced by hypoxia/ischemia. Although ORP150 was sparingly upregulated in neurons from human brain undergoing ischemic stress, there was robust induction in astrocytes. Cultured neurons overexpressing ORP150 were resistant to hypoxemic stress, whereas astrocytes with inhibited ORP150 expression were more vulnerable. Mice with targeted neuronal overexpression of ORP150 had smaller strokes compared with controls. Neurons with increased ORP150 demonstrated suppressed caspase-3-like activity and enhanced brain-derived neurotrophic factor (BDNF) under hypoxia signaling. These data indicate that ORP150 is an integral participant in ischemic cytoprotective pathways.
被引量：65 发表：2001
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CYP3A genetics in drug metabolism.
被引量：31 发表：2001
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Sir John Sulston.
被引量：- 发表：2001
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Induction of tumor lymphangiogenesis by VEGF-C promotes breast cancer metastasis.
:Metastasis of breast cancer occurs primarily through the lymphatic system, and the extent of lymph node involvement is a key prognostic factor for the disease. Whereas the significance of angiogenesis for tumor progression has been well documented, the ability of tumor cells to induce the growth of lymphatic vessels (lymphangiogenesis) and the presence of intratumoral lymphatic vessels have been controversial. Using a novel marker for lymphatic endothelium, LYVE-1, we demonstrate here the occurrence of intratumoral lymphangiogenesis within human breast cancers after orthotopic transplantation onto nude mice. Vascular endothelial growth factor (VEGF)-C overexpression in breast cancer cells potently increased intratumoral lymphangiogenesis, resulting in significantly enhanced metastasis to regional lymph nodes and to lungs. The degree of tumor lymphangiogenesis was highly correlated with the extent of lymph node and lung metastases. These results establish the occurrence and biological significance of intratumoral lymphangiogenesis in breast cancer and identify VEGF-C as a molecular link between tumor lymphangiogenesis and metastasis.
被引量：583 发表：2001
