自引率: 3.2%
被引量: 54819
通过率: 暂无数据
审稿周期: 2.67
版面费用: 暂无数据
国人发稿量: 5
投稿须知/期刊简介:
Immunity publishes reports of novel results in any area of immunology. The work should be not only of unusual significance within its field but also of interest to researchers outside the immediate area.
期刊描述简介:
Immunity publishes reports of novel results in any area of immunology. The work should be not only of unusual significance within its field but also of interest to researchers outside the immediate area.
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Notch signaling regulates macrophage-mediated inflammation in metabolic dysfunction-associated steatotic liver disease.
被引量：- 发表：1970
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Conversion of vaccines from low to high immunogenicity by antibodies with epitope complementarity.
被引量：- 发表：1970
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Tumor-reactive T cell clonotype dynamics underlying clinical response to TIL therapy in melanoma.
被引量：1 发表：1970
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Microbes and metabolites in immunity.
The immune system has a vital, albeit complex, relationship with the microbes residing within us, one that we are only beginning to understand. We asked investigators what they felt were the fundamental challenges we currently face in unraveling the impacts of microbes and their metabolites on host immunity and to discuss key opportunities toward achieving future insights and innovation.
被引量：- 发表：2024
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Autoantigen-specific CD4(+) T cells acquire an exhausted phenotype and persist in human antigen-specific autoimmune diseases.
Pro-inflammatory autoantigen-specific CD4+ T helper (auto-Th) cells are central orchestrators of autoimmune diseases (AIDs). We aimed to characterize these cells in human AIDs with defined autoantigens by combining human leukocyte antigen (HLA)-tetramer-based and activation-based multidimensional ex vivo analyses. In aquaporin4-antibody-positive neuromyelitis optica spectrum disorder (AQP4-NMOSD) patients, auto-Th cells expressed CD154, but proliferative capacity and pro-inflammatory cytokines were strongly reduced. Instead, exhaustion-associated co-inhibitory receptors were expressed together with FOXP3, the canonical regulatory T cell (Treg) transcription factor. Auto-Th cells responded in vitro to checkpoint inhibition and provided potent B cell help. Cells with the same exhaustion-like (ThEx) phenotype were identified in soluble liver antigen (SLA)-antibody-autoimmune hepatitis and BP180-antibody-positive bullous pemphigoid, AIDs of the liver and skin, respectively. While originally described in cancer and chronic infection, our data point to T cell exhaustion as a common mechanism of adaptation to chronic (self-)stimulation across AID types and link exhausted CD4+ T cells to humoral autoimmune responses, with implications for therapeutic targeting.
被引量：- 发表：1970
