自引率: 1.8%
被引量: 9742
通过率: 暂无数据
审稿周期: 暂无数据
版面费用: 暂无数据
国人发稿量: 4
投稿须知/期刊简介:
Developmental Dynamics an official publication of the American Association of Anatomists provides a focus for communication among developmental biologists who study the emergence of form during animal development. The journal is an international forum for the exchange of novel and significant information gained from analytical and theoretical investigations on the mechanisms that control morphogenesis. Developmental Dynamics seeks manuscripts on work done at all levels of biological organization ranging from the molecular to the organismal. Representative topics of Interest Include: Mechanisms underlying morphogenesis Pattern formation Tissue organization and repair Transcriptional and post-transcriptional controls governing the emergence of diverse biologic form Analytical methods for the visualization of molecular cytologic and ultrastructural aspects of dynamic developmental processes Cell-cell signalling and cell-matrix interactions Genetic and molecular probes for the study of cell lineages and developmental pathways Transgenic approaches for studying the control of tissue- and organ-specific gene expression Mathematical models of morphogenetic processes.
期刊描述简介:
Developmental Dynamics, is an official publication of the American Association of Anatomists. This peer reviewed journal provides an international forum for publishing novel discoveries, using any model system, that advances our understanding of development, morphology, form and function, evolution, disease, stem cells, repair and regeneration.
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Expression analysis of genes including Zfhx4 in mice and zebrafish reveals a temporospatial conserved molecular basis underlying craniofacial development.
被引量：- 发表：1970
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Ventral body wall closure: Mechanistic insights from mouse models and translation to human pathology.
被引量：- 发表：1970
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Effects of life history strategies and habitats on limb regeneration in plethodontid salamanders.
被引量：- 发表：1970
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Developmental ecology in embryos of an estuarine pupfish endemic of the Yucatan peninsula: Survival out of water, metabolic depression, and asynchronous hatching.
被引量：- 发表：1970
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Increased Netrin downstream of overactive Hedgehog signaling disrupts optic fissure formation.
Uveal coloboma, a developmental eye defect, is caused by failed development of the optic fissure, a ventral structure in the optic stalk and cup where axons exit the eye and vasculature enters. The Hedgehog (Hh) signaling pathway regulates optic fissure development: loss-of-function mutations in the Hh receptor ptch2 produce overactive Hh signaling and can result in coloboma. We previously proposed a model where overactive Hh signaling disrupts optic fissure formation by upregulating transcriptional targets acting both cell- and non-cell-autonomously. Here, we examine the Netrin family of secreted ligands as candidate Hh target genes. We find multiple Netrin ligands upregulated in the zebrafish ptch2 mutant during optic fissure development. Using a gain-of-function approach to overexpress Netrin in a spatiotemporally specific manner, we find that netrin1a or netrin1b overexpression is sufficient to cause coloboma and disrupt wild-type optic fissure formation. We used loss-of-function alleles, CRISPR/Cas9 mutagenesis, and morpholino knockdown to test if loss of Netrin can rescue coloboma in the ptch2 mutant: loss of netrin genes does not rescue the ptch2 mutant phenotype. These results suggest that Netrin is sufficient but not required to disrupt optic fissure formation downstream of overactive Hh signaling in the ptch2 mutant.
被引量：- 发表：1970
