自引率: 0.1%
被引量: 5345
通过率: 暂无数据
审稿周期: 暂无数据
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国人发稿量: 1
投稿须知/期刊简介:
Seminars in Immunology is a review journal dedicated to keeping scientists informed of developments in the field of immunology on a topic by topic basis. Each issue is thematic in approach, devoted to an important topic of interest to immunologists, focusing on recent advances across a broad spectrum of research, from the molecular and cellular basis of the immune response to the possibilities for its manipulation. Every issue is edited by a guest editor, an internationally acknowledged expert in the field, and contains six to eight authoritative invited reviews on different aspects of the subject area. The aim of each issue is to provide a coordinated, readable, and lively review of a selected area, published rapidly to ensure currency.
期刊描述简介:
Seminars in Immunology is a review journal dedicated to keeping scientists informed of developments in the field of immunology on a topic by topic basis. Each issue is thematic in approach, devoted to an important topic of interest to immunologists, focusing on recent advances across a broad spectrum of research, from the molecular and cellular basis of the immune response to the possibilities for its manipulation. Every issue is edited by a guest editor, an internationally acknowledged expert in the field, and contains six to eight authoritative invited reviews on different aspects of the subject area. The aim of each issue is to provide a coordinated, readable, and lively review of a selected area, published rapidly to ensure currency.
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The origins, manifestations, and potential treatments of allergic disorders.
被引量：- 发表：1970
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Early life microbiome influences on development of the mucosal innate immune system.
The gut microbiota is well known to possess immunomodulatory capacities, influencing a multitude of cellular signalling pathways to maintain host homeostasis. Although the formation of the immune system initiates before birth in a sterile environment, an emerging body of literature indicates that the neonatal immune system is influenced by a first wave of external stimuli that includes signals from the maternal microbiota. A second wave of stimulus begins after birth and must be tightly regulated during the neonatal period when colonization of the host occurs concomitantly with the maturation of the immune system, requiring a fine adjustment between establishing tolerance towards the commensal microbiota and preserving inflammatory responses against pathogenic invaders. Besides integrating cues from commensal microbes, the neonatal immune system must also regulate responses triggered by other environmental signals, such as dietary antigens, which become more complex with the introduction of solid food during the weaning period. This "window of opportunity" in early life is thought to be crucial for the proper development of the immune system, setting the tone of subsequent immune responses in adulthood and modulating the risk of developing chronic and metabolic inflammatory diseases. Here we review the importance of host-microbiota interactions for the development and maturation of the immune system, particularly in the early-life period, highlighting the known mechanisms involved in such communication. This discussion is focused on recent data demonstrating microbiota-mediated education of innate immune cells and its role in the development of lymphoid tissues.
被引量：2 发表：1970
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Introduction to the Special Issue: Pyroptosis in Immunity and Inflammation.
被引量：- 发表：1970
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Systems biology of B cells in COVID-19.
The integration of multi-'omic datasets into complex systems-wide assessments has become a mainstay in immunologic investigation. This focus on high-dimensional data collection and analysis was on full display in the investigation of COVID-19, the respiratory illness resulting from infection by the novel coronavirus SARS-CoV-2. Particularly in the area of B cell biology, tremendous efforts in both cellular and serologic investigation have resulted in an increasingly detailed mapping of the coordinated effector, memory, and antibody secreting cell responses that underpin the development of humoral immunity in response to primary viral infection. Further, the rapid development and deployment of effective vaccines has allowed for the assessment of developing memory responses across a wide variety of immune contexts, including in patients with compromised immune function. The result has been a period of rapid gains in the understanding of B cell biology unrestricted to the study of COVID-19. Here, we outline the systems-level technologies that have been routinely implemented in these investigations throughout the pandemic, and discuss how their use has led to clear and applicable gains in pursuance of the amelioration of human infectious disease and beyond.
被引量：- 发表：1970
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To die or not to die: Gasdermins in intestinal health and disease.
被引量：- 发表：1970
