投稿须知/期刊简介:

Bioorganic & Medicinal Chemistry Letters presents preliminary experimental or theoretical research results of outstanding significance and timeliness on all aspects of science at the interface of chemistry and biology and on major advances in drug design and development. The journal publishes preliminary communications in camera-ready form in much the same format as Tetrahedron Letters and strives to provide maximum dissemination to a large, international audience, the outstanding advances in bioorganic chemistry, bioinorganic chemistry and related disciplines. From 1996, Bioorganic & Medicinal Chemistry Letters is included in Tetrahedron Alert, the first phase of the Tetrahedron Information System. Tetrahedron Alert is the new electronic information service accessible via the Internet, and is a pre-publication service which provides the contents lists and graphical abstracts of current and forthcoming issues for all 5 of the Tetrahedron journals. Updated weekly Tetrahedron Alert offers: the option to view the contents list as graphical abstracts; the ability to search a single journal or across all 5 journals; search options using user-friendly query forms; hypertext links to facilitate navigation; the facility to print to your own printer. At any given time, Tetrahedron Alert contains approximately 3-4 months worth of current issues and accepted papers. A sampler which demonstrates the content and functionality of Tetrahedron Alert can be accessed via the Tetrahedron Information System Home Page at http://www.elsevier.nl/locate/tis.

期刊描述简介:

publishes research communications of outstanding significance and timeliness on topics at the interface of chemistry and biology, together with invited concise review articles. The journal publishes reports of experimental results in medicinal chemistry, chemical biology and drug discovery and design, emphasizing new and emerging advances and concepts in these fields. The aim of the journal is to promote a better understanding at the molecular level of life processes, and living organisms, as well as the interaction of these with chemical agents. The journal continues to be a major forum for the first publication of new chemical entities prior to them entering clinical trials. The Journal welcomes papers on: the medicinal chemistry and associated biology (including target identification and validation) of established or new disease targets the reporting of the discovery, design or optimization of potent new compounds or biological agents the analysis and discussion of structure-activity relationships and pharmacological issues relevant to drug design and action using in vitro and in vivo models, including the use of computational techniques when closely linked to experimental data the reporting of "first-in-class" new therapeutic compounds the chemical biology or bioorganic/bioinorganic chemistry that significantly advances knowledge of a biological mechanism methodological advances that are chemistry-based and which significantly impact on medicine or biology the preparation and examination of biotherapeutics for the treatment of pathophysiological disease states the development of materials for specific therapeutic targeting Manuscripts on phytochemistry, theoretical molecular dynamics and exclusively computational papers are out of scope. All manuscripts will be rigorously peer-reviewed by independent experts following an initial assessment by the Editors. Please note that BMCL is not suitable for straightforward reports of incremental advances. Above all the presentation of a rational basis and a sound underlying hypothesis for the work is of particular importance, whatever its exact field.