自引率: 4.3%
被引量: 16822
通过率: 暂无数据
审稿周期: 3.67
版面费用: 暂无数据
国人发稿量: 17
投稿须知/期刊简介:
The European Journal of Pharmaceutics and Biopharmaceutics provides a medium for publication of novel and innovative research from the areas of Pharmaceutical Technology, Pharmaceutical Biotechnology and Biopharmaceutics. Topics covered include: • Drug and pro-drug design, drug stability and drug development<br style="box-sizing: border-box; margin: 0px; padding: 0px; vertical-align: baseline; user-select: text !important;"> • Development, formulation and manufacturing of pharmaceuticals and biopharmaceuticals<br style="box-sizing: border-box; margin: 0px; padding: 0px; vertical-align: baseline; user-select: text !important;"> • Physical pharmacy, drug delivery systems, controlled release systems and drug targeting<br style="box-sizing: border-box; margin: 0px; padding: 0px; vertical-align: baseline; user-select: text !important;"> • Biopharmaceutics<br style="box-sizing: border-box; margin: 0px; padding: 0px; vertical-align: baseline; user-select: text !important;"> • Pharmaceutical analysis and pharmaceutical packaging<br style="box-sizing: border-box; margin: 0px; padding: 0px; vertical-align: baseline; user-select: text !important;"> • Quality control, GMP and regulatory aspects<br style="box-sizing: border-box; margin: 0px; padding: 0px; vertical-align: baseline; user-select: text !important;"> • Medical devices "The Rules of 3"<br style="box-sizing: border-box; margin: 0px; padding: 0px; vertical-align: baseline; user-select: text !important;"> The Editors and Editorial board have developed the "Rules of 3". Authors must consider the following three criteria before they submit a manuscript and set the whole process of editing and reviewing at work: 1. The paper must report on recent advances in pharmaceutical technology, biopharmaceutics and pharmaceutical biotechnology of major importance<br style="box-sizing: border-box; margin: 0px; padding: 0px; vertical-align: baseline; user-select: text !important;"> 2. A paper must be based on a thorough and extensive study, using established or well-described methods and including proper controls. Research must be hypothesis-driven and conclusions must be supported by the data presented.<br style="box-sizing: border-box; margin: 0px; padding: 0px; vertical-align: baseline; user-select: text !important;"> 3. The study described in the manuscript must represent a novel approach The rules are also used as guidelines for the peer review of manuscripts. CLICK HERE to view the "Rules of 3".
期刊描述简介:
The European Journal of Pharmaceutics and Biopharmaceutics provides a medium for publication of novel and innovative research from the areas of Pharmaceutical Technology, Pharmaceutical Biotechnology and Biopharmaceutics. Topics covered include: • Drug and pro-drug design, drug stability and drug development • Development, formulation and manufacturing of pharmaceuticals and biopharmaceuticals • Physical pharmacy, drug delivery systems, controlled release systems and drug targeting • Biopharmaceutics • Pharmaceutical analysis and pharmaceutical packaging • Quality control, GMP and regulatory aspects • Medical devices "The Rules of 3" The Editors and Editorial board have developed the "Rules of 3". Authors must consider the following three criteria before they submit a manuscript and set the whole process of editing and reviewing at work: 1. The paper must report on recent advances in pharmaceutical technology, biopharmaceutics and pharmaceutical biotechnology of major importance 2. A paper must be based on a thorough and extensive study, using established or well-described methods and including proper controls. Research must be hypothesis-driven and conclusions must be supported by the data presented. 3. The study described in the manuscript must represent a novel approach The rules are also used as guidelines for the peer review of manuscripts. CLICK HERE to view the "Rules of 3".
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Antifungal peptide-loaded alginate microfiber wound dressing evaluated against Candida albicans in vitro and ex vivo.
Invasive fungal infections have high mortality rates, and many current antimycotics are limited by host toxicity and drug resistance. Recent experiments in our laboratory have demonstrated the antifungal activity of dKn2-7, a synthetic peptide, against Candida albicans. The purpose of the current study was to develop a wound dressing capable of dKn2-7 release for extended periods to help combat fungal infection in wounds. dKn2-7 was incorporated into calcium alginate microfibers, an excipient with known wound healing and hemostatic properties. dKn2-7 release rates from the fibers were dependent on drug loading, but all formulations exhibited a burst release with 41-71 % of total theoretical release in the first 15 min and 84-96 % release by 24 h. Calcium release at 15 min was similar to that of a commercial hemostatic dressing, indicating dKn2-7 loading would not adversely affect the hemostatic capability of the alginate fibers. In vitro antifungal studies indicated a dose dependent effect with fibers loaded at ≥20 µg/mg causing significant planktonic killing and ≥30 µg/mg causing significant biofilm killing. Viable fungal counts in biofilms grown on ex vivo porcine skin declined by 99 % following 500 µg/mg fiber treatment. Skin histology indicated no significant differences in tissue damage between treatment groups and controls. Results confirm calcium alginate microfibers are capable of binding and subsequently releasing dKn2-7 over a 24-h period when rehydrated. Furthermore, dKn2-7 released from the fibers was able to significantly reduce biofilms in an ex vivo model with minimal toxicity, indicating these dKn2-7-loaded fiber dressings may be effective at controlling C. albicans biofilm infections in vivo.
被引量:- 发表:1970
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Pharmaceutical approaches for enhancing solubility and oral bioavailability of poorly soluble drugs.
被引量:- 发表:1970
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Intratracheal delivery of macrophage targeted Celastrol-loaded PLGA nanoparticles for enhanced anti-inflammatory efficacy in acute lung injury mice.
被引量:- 发表:1970
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Targeted nanomedicine for reprogramming the tumor innate immune system: From bench to bedside.
被引量:- 发表:1970
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Advancing pharmaceutical Intelligence via computationally Prognosticating the in-vitro parameters of fast disintegration tablets using Machine Learning models.
被引量:- 发表:1970