自引率: 17.9%
被引量: 7344
通过率: 暂无数据
审稿周期: 1.69
版面费用: 暂无数据
国人发稿量: 65
投稿须知/期刊简介:
The Archives of Gynecology and Obstetrics was founded in 1870 as "Archiv für Gynaekologie" and has a long and outstanding tradition. Since 1922 the journal has been the Organ of the Deutsche Gesellschaft für Gynäkologie und Geburtshilfe and publishes the abstracts and proceedings of their bi-annual meetings. The Archives of Gynecology and Obstetrics is circulated in over 40 countries world wide and is indexed in Current Contents and Index Medicus. The Archives of Gynecology and Obstetrics publishes " invited and submitted reviews " original articles about clinical topics and basic Research " case reports and " preliminary communications from all subspecialities in Gynecology and Obstetrics. All papers are peer-reviewed and published as quickly as possible.<br style="user-select: text !important;">The Archives of Gynecology and Obstetrics publishes<br style="user-select: text !important;"><br style="user-select: text !important;">-Editorials<br style="user-select: text !important;">-Letters to the Editor<br style="user-select: text !important;">-News and Views<br style="user-select: text !important;">-Reviews<br style="user-select: text !important;">-Original articles about clinical topics and basic research in the categories:<br style="user-select: text !important;"> Maternal Fetal Medicine<br style="user-select: text !important;"> General Gyneocology<br style="user-select: text !important;"> Gynecologic Oncology<br style="user-select: text !important;"> Gynecologic Endocrinology and Reproductive Medicine<br style="user-select: text !important;"> Urogynecology<br style="user-select: text !important;">-Position Statements and Guidelines<br style="user-select: text !important;">-Correspondence<br style="user-select: text !important;">-Images in Obstetrics and Gynecology<br style="user-select: text !important;">-Erratum<br style="user-select: text !important;">-Abstracts<br style="user-select: text !important;"><br style="user-select: text !important;">from all subspecialties in Gynecology and Obstetrics. All papers are peer-reviewed and published as quickly as possible. Case reports can be submitted, but will only be accepted if they are of broad interest to the community and include a systematic review of the literature if possible.
期刊描述简介:
The Archives of Gynecology and Obstetrics was founded in 1870 as "Archiv für Gynaekologie" and has a long and outstanding tradition. Since 1922 the journal has been the Organ of the Deutsche Gesellschaft für Gynäkologie und Geburtshilfe and publishes the abstracts and proceedings of their bi-annual meetings. The Archives of Gynecology and Obstetrics is circulated in over 40 countries world wide and is indexed in Current Contents and Index Medicus. The Archives of Gynecology and Obstetrics publishes " invited and submitted reviews " original articles about clinical topics and basic Research " case reports and " preliminary communications from all subspecialities in Gynecology and Obstetrics. All papers are peer-reviewed and published as quickly as possible. The Archives of Gynecology and Obstetrics publishes -Editorials -Letters to the Editor -News and Views -Reviews -Original articles about clinical topics and basic research in the categories: Maternal Fetal Medicine General Gyneocology Gynecologic Oncology Gynecologic Endocrinology and Reproductive Medicine Urogynecology -Position Statements and Guidelines -Correspondence -Images in Obstetrics and Gynecology -Erratum -Abstracts from all subspecialties in Gynecology and Obstetrics. All papers are peer-reviewed and published as quickly as possible. Case reports can be submitted, but will only be accepted if they are of broad interest to the community and include a systematic review of the literature if possible.
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Prognostic and clinical heterogeneity of PD1 and PD-L1- immunohistochemical scores in endometrial cancers.
PD1/PD-L1 inhibition (ICi) has recently become a new standard of care for patients with advanced MMR-deficient (MMRd) endometrial cancers. Nevertheless, response to immunotherapy is more complex than the presence of a single biomarker and therefore it remains challenging to predict patients response to ICi beyond MMRd tumors. Elevated PD-L1 expression (CPS ≥ 1) is often used as a prognostic marker as well as a predictive biomarker of response to ICi in different tumor types. In a retrospective, patient derived study, we analyzed PD1- and PD-L1 staining and correlated the results of different scores to clinical data to evaluate the prognostic impact of these scores. Immunohistochemical analysis of the receptor PD1 and the receptor ligand PD-L1 were performed on TMAs of primary paraffin‑embedded tumor samples. All patients were treated for primary endometrial cancer in the Department of Gynecology and Obstetrics, University Medical Center Schleswig-Holstein, Campus-Lübeck, Germany between the years 2006-2018. The evaluation and determination of the tumor proportion scoring (TPS), the combined positive score (CPS) and the immune cell scoring (IC) was automatically assessed semi-quantitatively, and results were correlated with clinicopathological characteristics and survival. 130 samples were evaluable and 64% showed a positivity (IC > 0) for the receptor PD1 and 56% for the receptor ligand PD-L1. Patients with a PD1 IC Score ≥ 1 showed a significant longer disease-free survival of 140 months (95% confidence interval (CI): 124-158) compared to patients with a lower IC < 1 for PD1 of 89 months (95% confidence interval (CI): 69-110); p = 0.017). Furthermore, the disease-free survival for patients with a CPS ≥ 5 for PD1 was longer (153.7 months (95% confidence interval (CI): 134-173.6) vs. 98.6 months (95% confidence interval (CI): 83-114); p = 0.036). Additionally, a PD1 CPS ≥ 5 showed a better overall survival but the result was not statistically significant. No difference in survival was found between patients with PD-L1 higher or lower than CPS 5. In this study we pointed out that there are significant clinical differences among several immunohistochemical scoring systems. In our trial, a PD1-positivity with CPS ≥ 5 and IC ≥ 1 were significantly associated to a better disease-free survival while there was no association with TPS. The PD1-IC scoring was associated with MMRd while the TPS scoring was not. Therefore, PD1-IC could be more appropriate for endometrial carcinomas compared to TPS and could also add prognostic information beside the more established PD-L1-staining. Further prospective studies are needed for a validation of these scores in combination with other biomarkers.
被引量：- 发表：1970
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Cervical length evolution in pregnancy and prediction of preterm delivery.
被引量：- 发表：1970
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Trial of labor following cesarean among patients with polyhydramnios: a multicenter retrospective study.
被引量：1 发表：1970
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Improved contingent screening strategy increased trisomy 21 detection rate in the second trimester.
被引量：- 发表：1970
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Severe ovarian hyperstimulation syndrome following sole gonadotropin-releasing hormone (GnRH) agonist trigger: a case series and literature review.
被引量：- 发表：1970
