自引率: 3.1%
被引量: 2914
通过率: 暂无数据
审稿周期: 2
版面费用: 暂无数据
国人发稿量: 82
投稿须知/期刊简介:
Cancer Gene Therapy publishes the results of laboratory investigations, preclinical studies, and clinical trials in the field of gene transfer/gene therapy as applied to cancer research. Types of manuscripts considered include: Original Research Articles. Articles should include, as appropriate, a clear statement of purpose; a historical review when desirable; a description of the procedures, methods, and subjects or materials used (previously published procedures require only references to the original); a full report of the findings, including discussion and references to relevant findings of other researchers.
期刊描述简介:
Cancer Gene Therapy publishes the results of laboratory investigations, preclinical studies, and clinical trials in the field of gene transfer/gene therapy as applied to cancer research. Types of manuscripts considered include: Original Research Articles. Articles should include, as appropriate, a clear statement of purpose; a historical review when desirable; a description of the procedures, methods, and subjects or materials used (previously published procedures require only references to the original); a full report of the findings, including discussion and references to relevant findings of other researchers.
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Multifaceted role of microRNA-301a in human cancer: from biomarker potential to therapeutic targeting.
被引量：- 发表：1970
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Chronic stress promotes non-small cell lung cancer (NSCLC) progression through circMBOAT2 upregulation mediated by CTCF.
被引量：- 发表：1970
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Extracellular vesicle-based anti-HOXB7 CD8(+) T cell-specific vaccination strengthens antitumor effects induced by vaccination against Her2/neu.
被引量：- 发表：1970
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PARD6A promotes lung adenocarcinoma cell proliferation and invasion through Serpina3.
被引量：- 发表：1970
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Caveolin-1 knockout mitigates breast cancer metastasis to the lungs via integrin α3 dysregulation in 4T1-induced syngeneic breast cancer model.
Caveolin-1 (Cav-1) is a critical lipid raft protein playing dual roles as both a tumor suppressor and promoter. While its role in tumorigenesis, progression, and metastasis has been recognized, the explicit contribution of Cav-1 to the onset of lung metastasis from primary breast malignancies remains unclear. Here, we present the first evidence that Cav-1 knockout in mammary epithelial cells significantly reduces lung metastasis in syngeneic breast cancer mouse models. In vitro, Cav-1 knockout in 4T1 cells suppressed extracellular vesicle secretion, cellular motility, and MMP secretion compared to controls. Complementing this, in vivo analyses demonstrated a marked reduction in lung metastatic foci in mice injected with Cav-1 knockout 4T1 cells as compared to wild-type cells, which was further corroborated by mRNA profiling of the primary tumor. We identified 21 epithelial cell migration genes exhibiting varied expression in tumors derived from Cav-1 knockout and wild-type 4T1 cells. Correlation analysis and immunoblotting further revealed that Cav-1 might regulate metastasis via integrin α3 (ITGα3). In silico protein docking predicted an interaction between Cav-1 and ITGα3, which was confirmed by co-immunoprecipitation. Furthermore, Cav-1 and ITGα3 knockdown corroborated its role in metastasis in the cell migration assay.
被引量：- 发表：1970
