自引率: 4.4%
被引量: 1826
通过率: 暂无数据
审稿周期: 1
版面费用: 暂无数据
国人发稿量: 53
投稿须知/期刊简介:
Molecular and Cellular Probes provides a unique forum for research on the location, diagnosis, and monitoring of inherited and infectious disease utilizing nucleic acid techniques. Crossing the traditional boundaries of diagnostic and clinical medicine, the journal provides an invaluable common meeting ground for workers from a variety of fields. Special attention is given to papers dealing with Human Molecular Genetics and Infectious Diseases, including: The description and clinical evaluation of nucleic acid techniques; New improved strategies for the production of probes; New strategies for the generation and detection of signals from probes; Use of polymerase chain reaction and other gene amplification techniques; Methods applied to infectious disease; Diagnosis, prenatal diagnosis, and carrier detection of inherited disorders by nucleic acid technology; Analysis of risk factors in multifactorial disorders using DNA polymorphisms; Animal studies with relevance to human disease.
期刊描述简介:
MCP - Advancing biology through–omics and bioinformatic technologies wants to capture outcomes from the current revolution in molecular technologies and sciences. The journal has broadened its scope and embraces any high quality research papers, reviews and opinions in areas including, but not limited to, molecular biology, cell biology, biochemistry, immunology, physiology, epidemiology, ecology, virology, microbiology, parasitology, genetics, evolutionary biology, genomics (including metagenomics), bioinformatics, proteomics, metabolomics, glycomics, and lipidomics. Submissions with a technology-driven focus on understanding normal biological or disease processes as well as conceptual advances and paradigm shifts are particularly encouraged. The Editors welcome fundamental or applied research areas; pre-submission enquiries about advanced draft manuscripts are welcomed. Top quality research and manuscripts will be fast-tracked.
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Identification of circRNA-mediated competing endogenous RNA network involved in the development of cervical cancer.
被引量：- 发表：1970
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Prognostic prediction of gastric cancer based on H&E findings and machine learning pathomics.
被引量：- 发表：1970
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Genetic switch selectively kills hepatocellular carcinoma cell based on microRNA and tissue-specific promoter.
被引量：- 发表：1970
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New potential diagnostic markers for verrucous hyperplasia and verrucous carcinoma based on RNA-sequencing data.
Verrucous carcinoma (VC) is a rare subtype of squamous cell carcinoma (SCC) characterized by its histological presentation as a low-grade tumor with no potential for metastasis, setting it apart from invasive SCC. However, distinguishing VC from its benign counterpart, verrucous hyperplasia (VH), is challenging due to their clinical and morphological similarities. Despite the importance of accurate diagnosis for determining treatment strategies, diagnosis of VH and VC relied only on lesion recurrence after resection. To address this challenge, we generated RNA profiling data from tissue samples of VH and VC patients to identify novel diagnostic markers. We analyzed differentially expressed (DE) mRNA and long non-coding RNA (lncRNA) in tissue samples from VH and VC patients. Additionally, ChIP-X Enrichment Analysis 3 (ChEA3) was conducted to identify the top five transcription factors potentially regulating the expression of DE mRNAs in VH and VC. Our analysis of mRNA and lncRNA expression profiles in VH and VC provides insights into the underlying molecular characteristics of these diseases and offers potential new diagnostic markers. The identification of specific DE genes and lncRNAs may enable clinicians to more accurately differentiate between VH and VC, leading to better treatment choices.
被引量：- 发表：1970
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Performance of the Idylla microsatellite instability test in endometrial cancer.
DNA mismatch repair (MMR) deficiency (dMMR) testing is now recommended in endometrial cancer. Defect identification in the molecules participating in this pathway, or the presence of microsatellite instability, are commonly employed for this purpose. Novel methods are continuously evolving to report dMMR/microsatellite instability and to easily perform routine diagnoses. The main aim of this study was to compare the concordance of the Idylla microsatellite instability test for the identification of dMMR endometrial cancer samples defined by immunohistochemistry and MMR genomic status. We applied the Idylla MSI test to 126 early-stage endometrial cancer cases with MMR testing by immunohistochemistry and genomic characterization (methylation in MLH1 and sequence alterations in MLH1, PMS2, MSH2 and MSH6). Individual markers and overall specific performance indicators were explored. The Idylla platform achieved a higher global concordance rate with MMR genomic status than with immunohistochemistry (75 % and 66 %, respectively). Sensitivity and specificity are also higher (75 % vs 66 % and 96 % vs 90 %, respectively). Clustering analysis split the patients into 2 well-differentiated clusters, the pMMR and the dMMR group, represented by MLH1/PMS2 loss and the MLH1 methylated promoter. Overall, immunohistochemistry and MMR genomic status identified more dMMR cases than did the Idylla test, although correlations were improved with a modified Idylla test cut-off. Performance of the Idylla test was better correlated with MMR genomic status than MMR immunohistochemistry status, which improved with a modified test cut-off. Further studies are needed to confirm the cut-off accuracy.
被引量：- 发表：1970
