
自引率: 9%
被引量: 1941
通过率: 暂无数据
审稿周期: 暂无数据
版面费用: 暂无数据
国人发稿量: 24
投稿须知/期刊简介:
Cell Biology and Toxicology is an international journal which provides a rapid publication outlet for papers of high scientific standards in the areas of cell biology genetic molecular and cellular toxicology. The scope of publication includes scientific reports dealing with the basic biology and with the physiological pharmacological and toxic response of cellular systems. Studies of subcellular and cellular systems derived from both prokaryotic and eukaryotic cell types are appropriate. Studies of toxic effects may include but are not limited to cytotoxicity mutagenicity carcinogenicity and teratogenicity. Moreover investigations on the development of cell systems for these purposes are relevant. In particular the journal welcomes approaches to cellular studies or molecular structure activity correlations that provide sound scientific information leading to the reduced use of experimental animals. Cell Biology and Toxicology publishes several types of articles including papers describing original research results and reviews on subjects of contemporary importance to cell biologists and cell toxicologists. Also brief announcements of scientific meetings or courses and of the availability of funding fellowships and scholarships are published.
期刊描述简介:
Cell Biology and Toxicology is an international journal which provides a rapid publication outlet for papers of high scientific standards in the areas of cell biology genetic molecular and cellular toxicology. The scope of publication includes scientific reports dealing with the basic biology and with the physiological pharmacological and toxic response of cellular systems. Studies of subcellular and cellular systems derived from both prokaryotic and eukaryotic cell types are appropriate. Studies of toxic effects may include but are not limited to cytotoxicity mutagenicity carcinogenicity and teratogenicity. Moreover investigations on the development of cell systems for these purposes are relevant. In particular the journal welcomes approaches to cellular studies or molecular structure activity correlations that provide sound scientific information leading to the reduced use of experimental animals. Cell Biology and Toxicology publishes several types of articles including papers describing original research results and reviews on subjects of contemporary importance to cell biologists and cell toxicologists. Also brief announcements of scientific meetings or courses and of the availability of funding fellowships and scholarships are published.
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EIF4A3-mediated oncogenic circRNA hsa_circ_0001165 advances esophageal squamous cell carcinoma progression through the miR-381-3p/TNS3 pathway.
Esophageal squamous cell carcinoma (ESCC) remains a major clinical challenge due to its poor prognosis and the scarcity effective therapeutic targets. Circular RNAs (circRNAs) are crucial in cancer progression. In this study, high-throughput sequencing was employed to profile ESCC tissues, revealing that hsa_circ_0001165 is notably elevated in both ESCC tumor samples and cell lines, with its expression is positively associated with patients' TNM staging. Knockdown of hsa_circ_0001165 resulted in reduced malignant biological behavior of ESCC cells in vitro and also inhibited tumor growth in vivo. Mechanism experimental analysis found that hsa_circ_0001165 expression is positively enhanced by eukaryotic translation initiation factor 4A3 (EIF4A3). Hsa_circ_0001165 acts as a miRNA sponge for miR-381-3p, increasing the expression of tensin-3 (TNS3) through a series of related mechanism assays include dual-luciferase reporter gene, RNA Immunoprecipitation and RNA-pulldown. The downregulation in miR-381-3p expression was observed in ESCC tissues, and the cell proliferation, invasion, and migration of ESCC were suppressed. The upregulated expression of hsa_circ_0001165 modulates the miR-381-3p/TNS3 axis and promotes aggressive phenotypes of ESCC. Hsa_circ_0001165 is regarded as a encouraging biomarker and potential therapeutic target for ESCC, presenting innovative options for both diagnostic and treatment approaches.
被引量:- 发表:1970
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ACE2 alleviates sepsis-induced cardiomyopathy through inhibiting M1 macrophage via NF-κB/STAT1 signals.
被引量:- 发表:1970
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Neddylation signaling inactivation by tetracaine hydrochloride suppresses cell proliferation and alleviates vemurafenib-resistance of melanoma.
被引量:- 发表:1970
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Hepsin as a potential therapeutic target for alleviating acetaminophen-induced hepatotoxicity via gap-junction regulation and oxidative stress modulation.
被引量:- 发表:1970
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MicroRNA-155 and its exosomal form: Small pieces in the gastrointestinal cancers puzzle.
被引量:- 发表:1970