自引率: 3.4%
被引量: 3415
通过率: 暂无数据
审稿周期: 暂无数据
版面费用: 暂无数据
国人发稿量: 16
投稿须知/期刊简介:
The journal publishes results of original research on both basic and clinical aspects of the developing nervous system, ranging from simpler invertebrate systems and in vitro neural models to models of regeneration, chronic neurological diseases and aging. Papers concerned with both in vitro and in vivo studies are invited for editorial consideration. The journal will also publish original articles, editorials, reviews and communications from the International Society for Developmental Neuroscience covering all the latest developments in the field. Its main aims will be to facilitate the transfer of basic information to clinical applications and to promote an understanding of the fundamental mechanisms of neural growth, development and pathology. Those interested in joining the International Society for Developmental Neuroscience should write to Dr ReginoPerez-Polo, Secretary-General of the ISDN, at the Department of Human Biological Chemistry and Genetics, UTMB Galveston, TX 77555-0652, U.S.A. Fax: 409 772 8028, e-mail: jperezpo@mspol.med.utmb.edu
期刊描述简介:
he journal publishes results of original research on both basic and clinical aspects of the developing nervous system, ranging from simpler invertebrate systems and in vitro neural models to models of regeneration, chronic neurological diseases and aging. Papers concerned with both in vitro and in vivo studies are invited for editorial consideration. The journal will also publish original articles, editorials, reviews and communications from the International Society for Developmental Neuroscience covering all the latest developments in the field. Its main aims will be to facilitate the transfer of basic information to clinical applications and to promote an understanding of the fundamental mechanisms of neural growth, development and pathology. Those interested in joining the International Society for Developmental Neuroscience should write to Dr ReginoPerez-Polo, Secretary-General of the ISDN, at the Department of Human Biological Chemistry and Genetics, UTMB Galveston, TX 77555-0652, U.S.A. Fax: 409 772 8028, e-mail: jperezpo@mspol.med.utmb.edu
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Assessment of BDNF and sialic acid levels in children with ADHD: Relation of chronotypes.
被引量：- 发表：1970
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Novel variant related to SATB2-associated syndrome.
被引量：- 发表：1970
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Prediction of individual performance and verbal intelligence scores from resting-state fMRI in children and adolescents.
被引量：- 发表：1970
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Evaluation of developmental milestones and of brain measurements in rats exposed to the pesticide pyriproxyfen in prenatal period.
Pyriproxyfen is a pesticide used in Brazil to control the Aedes aegypti mosquito, vector of arboviruses like Zika and dengue. However, this pesticide is structurally similar to retinoic acid, a metabolite of vitamin A that regulates neuronal differentiation and hindbrain development during the embryonic period. Due to the similarity between pyriproxyfen and retinoic acid, studies indicate that this pesticide may have cross-reactivity with retinoid receptors. Thus, pregnant exposure to pyriproxyfen could interfere in the nervous system development of the fetal. In this context, the present study evaluated whether prenatal exposure to pyriproxyfen affects neonatal development and brain structure in rats. Wistar rat pups were divided in three experimental groups: (1) negative control (CT-)-offspring of rats that drink potable water during pregnancy; (2) pyriproxyfen (PIR)-offspring of rats exposed to Sumilarv® prenatally, a pesticide that has pyriproxyfen as active ingredient; and (3) positive control (CT+)-offspring of rats exposed to an excess of vitamin A prenatally. Only vitamin A treated-pregnant showed lower weight gain, but gestation length was similar among pregnant that received potable water, water containing vitamin A and water containing Sumilarv. In relation to the offspring, PIR group exhibits a delayed front-limb suspension response but performed early the negative geotaxis reflex. On the other hand, CT+ group exhibited lower body weight in the 1st postnatal day, delayed audio startle response, but performed early the eyelids opening and hindlimb placing response. A reduction in the maximum brain width was observed both in PIR and CT+ groups, but a reduction in the number of neurons in the M1 cortex was showed only in CT+ group. The number of glial cells in this brain area was similar between the three experimental groups studied. Although prenatal exposure to pyriproxyfen did not alter neonatal milestones in the same way as vitamin A in excess, both substances caused a reduction in the maximum width of the brain, suggesting that this pesticide can produce neurotoxic effects during the embryonic period.
被引量：- 发表：1970
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Melatonin attenuates affective disorders and cognitive deficits induced by perinatal exposure to a glyphosate-based herbicide via antioxidant pathway in adult male and female rats.
The massive use of herbicides, particularly glyphosate-based herbicides (GBHs), raises several worries, notably their neurotoxic effects. Several studies have explored the consequences of developmental exposure. Our work aims to determine the impact of maternal exposure to GBH on behavioral disorders and memory deficits, as well as the involvement of oxidative stress in the hippocampus and prefrontal cortex. In addition, our study explores the neuroprotective properties of melatonin in male and female offspring. Pregnant Wistar rats were injected with GBH 75 mg/kg during gestation and lactation. After weaning, the offspring were treated with melatonin (4 mg/kg) from postnatal days 30-58. Our results show that GBH increases anxiety-like behavior levels in offspring, as well as depression-like behavior. GBH also impairs working memory in progeny. While markers of oxidative stress show a disturbance in lipid peroxidation and catalase activity, with a more pronounced effect in females, on the other hand, melatonin considerably attenuated the neurotoxic impact observed in the offspring, with higher efficacy in females. The oxidative stress results confirm the antioxidant power of melatonin to counteract the damaging effects of exposure to environmental contaminants such as glyphosate-based pesticides. It will then be interesting to further our work to fully understand the sex-dependent effect of melatonin.
被引量：- 发表：1970
