自引率: 4.7%
被引量: 1313
通过率: 暂无数据
审稿周期: 1
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国人发稿量: 2
投稿须知/期刊简介:
Published by Medknow Publications. ISSN: 0377-4929.<br> The Indian Journal of Pathology and Microbiology is the official quarterly publication of the Indi
期刊描述简介:
Indian Journal of Pathology and Microbiology (ISSN-0377-4929) The Indian Journal of Pathology and Microbiology is the official Quarterly publication of the Indian Association of Pathologists and Microbiologists. It had completed 50 glorious years in the year 2007. Late Dr Vanmali Saran Maglik of King George Medical College, Lucknow is the founder editor who started the journal in the year 1958. Initially the journal was called Indian Journal of Pathology and Bacteriology and the present name is in existence from the year 1965. The journal grew over the years under the able guidance of stalwarts like Late Dr HI Jhala, Late Dr V Ramalingaswamy, Dr HD Tandon, Late Dr BK Aikat and Late Dr S Nagalotimath. The present form is due to the untiring efforts of Dr KS Ratnakar, Dr VH Talib, Dr SK Shahi and Dr Harsh Mohan. The journal is widely read and is in almost all the libraries of the country and in many institutions outside the country. From the year 2008, the article submission, review, correspondence and publication process has been made online (www.journalonweb.com/ijpm). Now the journal has its own website (www.ijpmonline.org). With these changes the visibility and popularity of the journal has tremendously increased. Dr S Satyanarayana is the present editor of the journal. Abstracting and Indexing Information The journal is registered with the following abstracting partners: Baidu Scholar, CNKI (China National Knowledge Infrastructure), EBSCO Publishing's Electronic Databases, Ex Libris – Primo Central, Google Scholar, Hinari, Infotrieve, National Science Library, ProQuest, TdNet, Wanfang Data The journal is indexed with, or included in, the following: DOAJ, EMBASE/ Excerpta Medica, Indian Science Abstracts, IndMed, MEDLINE/Index Medicus, Scimago Journal Ranking, SCOPUS, Science Citation Index Expanded, Web of Science Impact Factor® as reported in the 2017 Journal Citation Reports® (Clarivate Analytics, 2018): 0.529 Journal Ethics Wolters Kluwer and Journal/Association are committed to meeting and upholding standards of ethical behavior at all stages of the publication process. We follow closely the industry associations, such as the Committee on Publication Ethics (COPE), International Committee of Medical Journal Editors (ICMJE) and World Association of Medical Editors (WAME), that set standards and provide guidelines for best practices in order to meet these requirements. For a summary of our specific policies regarding duplicate publication, conflicts of interest, patient consent, etc., please visit www.Medknow.com/EthicalGuidelines.asp
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EBV-triggered secondary macrophage activation syndrome in the backdrop of lupus in an adult.
被引量：- 发表：1970
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Immature platelet fraction in patients diagnosed with COVID-19.
The recent pandemic caused by the newly identified virus, SARS-Cov-2 is associated with thromboembolic events. Patients infected with COVID-19 have been found to have thrombocytopenia. A decrease in platelet count may be caused by increased destruction and consumption of platelets or by decreased production of platelets in the bone marrow. Immature platelet fraction (IPF) is a new platelet parameter that is an indicator for peripheral destruction and consumption of platelets. To assess the immature platelet fraction (IPF) in patients infected with COVID-19. The present study is a retrospective study where secondary data obtained from previous laboratory records of COVID-positive patients admitted at a tertiary care hospital in Delhi from 4 January to 4 February 2022 was analyzed. Sixty-eight COVID-positive patients were included. Platelet parameters included from the automated hematology analyzer Mindray were platelet count, mean platelet volume (MPV), immature platelet fraction (IPF), and platelet large cell ratio (P-LCR). Data was analyzed using SPSS Version 25. A P value less than 0.05 was considered statistically significant. In the present study mild thrombocytopenia was noted in 40% of the patients infected with COVID-19 admitted to the hospital. The median platelet count in these patients was found to be 91,000/mm3 (64,000-1,31,000). Low platelet count was associated with a significantly higher IPF, MPV, PDW, P-LCR, and a significantly lower PCT as compared to patients infected with COVID-19 with normal platelet count. There was a significant increase in IPF with a decrease in platelet count (P value < 0.05). A significant increase in IPF was noted with an increase in MPV and P-LCR (P value < 0.05). The present study suggests that thrombocytopenia in patients infected with COVID-19 may probably be due to peripheral destruction and consumption of platelets.
被引量：- 发表：1970
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Potential for tumor aggressiveness and its association with vasculogenic mimicry marker in colorectal carcinomas in Indian population- A tertiary care hospital level study.
Vasculogenic mimicry (VM) is the ability of cancer stem cells of aggressive phenotype to mimic embryonic vascular network by forming channels lined by tumor cells, thereby, promoting tumor growth. These channels are periodic acid-schiff positive and CD34 negative and have been associated with tumor invasion, metastasis, and poor prognosis. It is a promising target for developing novel anticancer therapeutics and contributes to personalized medicine. Our study aims to look for an association of vasculogenic mimicry marker (VMM) with the aggressiveness of colorectal carcinomas (CRCs). All retrospective and prospective cases of colorectal adenocarcinomas received over period of five years, from 2017 to 2021 were included in this study and a case-control study was planned. The study population was divided into two comparison groups based on TNM staging (a) those with non-aggressive tumors (controls; TNM stage I and II) and (b) those with aggressive tumors (cases; TNM stage III and IV). A total of 36 controls and 27 cases were studied. Hematoxylin and eosin stain, PAS, and CD34 immunohistochemistry were conducted. PAS positivity with negative CD34 in the same case was designated as VMM positive. VMM status was correlated with tumor stage, grade, and other pathological markers of prognosis. The Chi-square test was used to find an association between the aggressiveness of CRCs and VM positivity. The P value < 0.05 was considered to be significant. It was found that VMM was significantly associated with the aggressiveness of CRCs. VMM is a promising marker for its clinical utility in day-to-day routine IHC studies and its positivity correlates with tumor aggressiveness.
被引量：- 发表：1970
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The mechanism by which intestinal flora metabolites regulate ILC2s transformation and intestinal immunity through the metabolite-sensitive receptor Ffar2.
The objective of this article was to investigate how the metabolites produced by the intestinal flora regulate the transformation of ILC2s and intestinal immunity via the receptor Ffar2, which is sensitive to metabolites. Forty male C57BL/6 mice with wild-type characteristics (6-7 weeks in age) and 20 FFAR2-/- mice were acquired from The Jackson Laboratory. The mice were kept in a controlled environment without any disease-causing agents, with the help of air conditioning and a 12-hour cycle of light and darkness. Throughout the experiment, every mouse was provided with unrestricted availability of both food and water. All protocols were performed following the Regulations of Animal Welfare and the recommendations for Animal Testing. According to the research protocol, the mice were categorized into three groups, each consisting of 20 mice. FFAR2-/- mice in the FFAR2-/- group were reared in conventional environments. Male C57BL/6 mice with wild-type characteristics were reared in conventional conditions in the wild-type group. In the group where wild-type mice were inhibited with Ffar2, a total of 20 mice with the wild-type phenotype were chosen to receive intraperitoneal injection of an FFAR2 antagonist at a dosage of 5 mg/kg per day for a continuous period of 3 weeks. qRT-PCR was used to detect the expression of FFAR2 mRNA in the mucosal tissue of the mouse colon. High-throughput sequencing was used to conduct an examination of metabolites in the intestinal tract of mice. Flow cytometry was used to test the quantity of ILC2s. ELISA was used to measure the levels of IL-5 and IL-13 in cellular mouse intestinal mucosal tissues. Flow cytometry was used to detect the quantity of CD4+ and CD8+ T cells. CCL20 and CCL25 expression was analyzed by Western blotting. The level of FFAR2 mRNA expression was higher in the wild-type group than the FFAR2-/- group (P < 0.05), while it was lower in the wild-type + Ffar2 inhibition group than the wild-type group (P < 0.05). No variations were observed in the composition of metabolites and levels of major SCFAs in the gut microbiota of mice across all groups (P > 0.05). The quantity of CRTH2+ and ST2+ cells in the wild-type category exceeded that in the FFAR2-/- category (P < 0.05), whereas the quantity of CRTH2+ and ST2+ cells in the wild-type + Ffar2 inhibition category was lower than that in the wild-type category (P < 0.05). The concentrations of IL-5 and IL-13 were higher in the wild-type group compared with the FFAR2-/- group (P < 0.05), while the wild-type + Ffar2 inhibition group exhibited lower levels of IL-5 and IL-13 than the wild-type group (P < 0.05). The count of CD4+ T cells and CD8+ T cells in the wild-type group showed an increase in comparison to the FFAR2-/- group (P < 0.05), whereas the count of CD4+ T cells and CD8+ T cells in the wild-type + Ffar2 inhibition group exhibited a decrease in comparison to the wild-type group (P < 0.05). The levels of protein expression for CCL20 and CCL25 were higher in the wild-type group compared with the FFAR2-/- group (P < 0.05), whereas the wild-type + Ffar2 inhibition group exhibited lower protein expression of CCL20 and CCL25 than the wild-type group (P < 0.05). Ffar2 has a significant regulatory function in the conversion of ILC2s, consequently impacting the immune response in the intestines. Ffar2, a crucial receptor for metabolites produced by the intestinal flora, plays a vital function in controlling the conversion of ILC2s and the overall immune response in the intestines.
被引量：- 发表：1970
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Advanced female urethral adenocarcinoma: A case report.
Urethral cancer in females is a rare occurrence. Although initially believed to be derived from skene glands, there is no consensus on the cell of origin. Squamous cell carcinoma is the most common, whereas adenocarcinoma is the least common. We report the case of a 58-years-old lady with a history of voiding lower urinary tract symptoms, later requiring a suprapubic cystostomy for retention. Cystoscopy and biopsy showed prostate-specific antigen (PSA) negative adenocarcinoma and postiron emission computed tomography (PETCT) showing pelvic and inguinal nodal metastasis. The patient underwent neoadjuvant chemotherapy followed by anterior exenteration with pelvic lymphadenectomy and ileal conduit. Final histology showed ypT4 yN1 adenocarcinoma, not otherwise specified.
被引量：- 发表：1970
