自引率: 8.5%
被引量: 10930
通过率: 暂无数据
审稿周期: 1.67
版面费用: 暂无数据
国人发稿量: 31
投稿须知/期刊简介:
Official journal of EUROTOX Edited on behalf of the Deutsche Gesellschaft für Experimentelle und Klinische Pharmakologie und Toxikologie The provision of up-to-date information on the latest advances in toxicology is one of the main services that Archives of Toxicology offers its readers. Particular emphasis is laid on studies relating to defined effects of chemicals and mechanisms of toxicity including toxic activities at the molecular level in humans and experimental animals. Space is also devoted to new insights into analysis and toxicokinetics and to forensic toxicology. Review articles of general interest to toxicologists are a further important feature of the journal. Experimental and clinical data relating to toxicology can be submitted for publication in Archives of Toxicology as Original investigations Review articles Short communications or Letters to the editors.
期刊描述简介:
Official journal of EUROTOX Edited on behalf of the Deutsche Gesellschaft für Experimentelle und Klinische Pharmakologie und Toxikologie The provision of up-to-date information on the latest advances in toxicology is one of the main services that Archives of Toxicology offers its readers. Particular emphasis is laid on studies relating to defined effects of chemicals and mechanisms of toxicity including toxic activities at the molecular level in humans and experimental animals. Space is also devoted to new insights into analysis and toxicokinetics and to forensic toxicology. Review articles of general interest to toxicologists are a further important feature of the journal. Experimental and clinical data relating to toxicology can be submitted for publication in Archives of Toxicology as Original investigations Review articles Short communications or Letters to the editors
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Revisiting cadmium-induced toxicity in the male reproductive system: an update.
被引量：- 发表：1970
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An integrated multi-omics analysis of the effects of the food processing-induced contaminant 2-monochloropropane-1,3-diol (2-MCPD) in rat heart.
被引量：- 发表：1970
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Neutralizing chimeric heavy-chain antibody targeting the L-HN domain of Clostridium botulinum neurotoxin type F.
被引量：- 发表：1970
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The phytochemical plumbagin: mechanism behind its "pleiotropic" nature and potential as an anticancer treatment.
被引量：- 发表：1970
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Towards characterization of cell culture conditions for reliable proteomic analysis: in vitro studies on A549, differentiated THP-1, and NR8383 cell lines.
Proteomic investigations result in high dimensional datasets, but integration or comparison of different studies is hampered by high variances due to different experimental setups. In addition, cell culture conditions can have a huge impact on the outcome. This study systematically investigates the impact of experimental parameters on the proteomic profiles of commonly used cell lines-A549, differentiated THP-1 macrophage-like cells, and NR8383-for toxicity studies. The work focuses on analyzing the influence at the proteome level of cell culture setup involving different vessels, cell passage numbers, and post-differentiation harvesting time, aiming to improve the reliability of proteomic analyses for hazard assessment. Mass-spectrometry-based proteomics was utilized for accurate protein quantification by means of a label-free approach. Our results showed that significant proteome variations occur when cells are cultivated under different setups. Further analysis of these variations revealed their association to specific cellular pathways related to protein misfolding, oxidative stress, and proteasome activity. Conversely, the influence of cell passage numbers on the proteome is minor, suggesting a reliable range for conducting reproducible biological replicates. Notable, substantial proteome alterations occur over-time post-differentiation of dTHP-1 cells, particularly impacting pathways crucial for macrophage function. This finding is key for the interpretation of experimental results. These results highlight the need for standardized culture conditions in proteomic-based evaluations of treatment effects to ensure reliable results, a prerequisite for achieving regulatory acceptance of proteomics data.
被引量：- 发表：1970
