自引率: 4.1%
被引量: 3777
通过率: 暂无数据
审稿周期: 暂无数据
版面费用: 暂无数据
国人发稿量: 12
投稿须知/期刊简介:
In 1869 the Archives of Dermatological Research was founded as Archiv für Dermatologie und Syphilis by H. Auspitz and F. J. Pick. Continued and edited by A. Neisser L. v. Zumbusch J. Jadassohn W. Pick. Vols. 1-127 (1920) published by Braunmüller Vienna; as of Vol. 128 (1921) by Springer Berlin. From 1921 until 1973 organ of the Deutsche Dermatologische Gesellschaft (Vereinigung deutschsprachiger Dermatologen). As of Vol. 201 (1955) published as Archiv für klinische und experimentelle Dermatologie. As of Vol. 240 (1971) as Archiv für Dermatologische Forschung/Archives for Dermatological Research. As of Vol. 253 (1975) as Archives for Dermatological Research/Archiv für Dermatologische Forschung. As of Vol. 261 (1978) as Archives of Dermatological Research/Archiv für Dermatologische Forschung. As of Vol. 264 (1979) as Archives of Dermatological Research. Archives of Dermatological Research publishes original contributions in the field of experimental dermatology including papers on biochemistry morphology and immunology of the skin. Papers describing new techniques and methods are welcome if they contribute to the further understanding of skin problems. Archives of Dermatological Research guarantees rapid publication of: Original papers · Short communications · Letters to the editor. Archives of Dermatological Research is a highly rated journal with a large international readership. All of the articles are written in English.
期刊描述简介:
In 1869 the Archives of Dermatological Research was founded as Archiv für Dermatologie und Syphilis by H. Auspitz and F. J. Pick. Continued and edited by A. Neisser L. v. Zumbusch J. Jadassohn W. Pick. Vols. 1-127 (1920) published by Braunmüller Vienna; as of Vol. 128 (1921) by Springer Berlin. From 1921 until 1973 organ of the Deutsche Dermatologische Gesellschaft (Vereinigung deutschsprachiger Dermatologen). As of Vol. 201 (1955) published as Archiv für klinische und experimentelle Dermatologie. As of Vol. 240 (1971) as Archiv für Dermatologische Forschung/Archives for Dermatological Research. As of Vol. 253 (1975) as Archives for Dermatological Research/Archiv für Dermatologische Forschung. As of Vol. 261 (1978) as Archives of Dermatological Research/Archiv für Dermatologische Forschung. As of Vol. 264 (1979) as Archives of Dermatological Research. Archives of Dermatological Research publishes original contributions in the field of experimental dermatology including papers on biochemistry morphology and immunology of the skin. Papers describing new techniques and methods are welcome if they contribute to the further understanding of skin problems. Archives of Dermatological Research guarantees rapid publication of: Original papers · Short communications · Letters to the editor. Archives of Dermatological Research is a highly rated journal with a large international readership. All of the articles are written in English.
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A novel KIT missense mutation in one Chinese family with piebaldism.
Piebaldism is an autosomal dominant disorder characterized by congenital leukoderma, mostly affecting forehead, abdomen and knee. Previous studies have revealed that piebaldism is caused by mutations of the KIT gene, which encodes the cell surface transmembrane tyrosine kinase receptor for KIT ligand. We reported here a Chinese Han family with piebaldism, and performed mutation detection of KIT gene by direct sequencing. A novel missense mutation C58G was identified in the patients, but not in the healthy individuals from the family and 100 unrelated controls. This study contributes to the database on KIT in piebaldism and enriches the knowledge about the genotype/phenotype correlation.
被引量：2 发表：1970
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Expression pattern of the lymphatic and vascular markers VEGFR-3 and CD31 does not predict regional lymph node metastasis in cutaneous melanoma.
Malignant melanoma of the skin preferentially metastasises via the lymphatic system. Novel molecular biomarkers, which are involved in malignant transformation, proliferation, angiogenesis and lymphangiogenesis, are currently under investigation to elucidate the risk for lymph node metastasis. To this end, the vascular endothelial growth factors VEGF-C and VEGF-D have been identified to promote lymphangiogenesis and lymphatic spread through activation of its receptor, Vascular endothelial growth factor receptor-3 (VEGFR-3). Prompted by this assumption, we estimated the degree of lymphangiogenesis by semiquantitative immunohistochemical analysis of the expression of VEGFR-3 and the panvascular marker CD31 in primary cutaneous melanoma (n=26) and correlated these findings with the sentinel lymph node (SLN) status. The cohort was selected for matched prognostic markers in SLN-positive and SLN-negative patients. In contrast to other studies, we observed an inverse correlation between expression of these markers with lymph node metastases. Additionally, no difference between intratumoral versus peritumoral CD31- or VEGFR-3 expression on blood vessels versus lymphatic capillaries could be detected. Interestingly, VEGFR-3 upregulation was not restrained to vascular structures but also appeared on tumor cells. In summary, in our series VEGFR-3/CD31 immunohistochemical staining of primary melanoma does not serve as a valid marker to predict lymph node involvement. As lymphatic spread is a complex, multi-step process, several different biomarkers have to be combined to define new prognostic subgroups in cutaneous melanoma.
被引量：8 发表：1970
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Role of androgens in female-pattern androgenetic alopecia, either alone or associated with other symptoms of hyperandrogenism.
:The roles of androgen hypersecretion, in situ enzyme activity, and androgen receptors in androgenetic alopecia in women are still a matter of debate. We studied 187 women with alopecia, which we graded I, II, or III, according to Ludwig's classification, and 21 healthy control women. All participants were subjected to full basal and 1 h post-beta-1-24 corticotropin stimulation endocrine profiles. Abnormal hormone profiles were observed in 67% of the patients with alopecia alone (group A, n = 110) and in 84% of the patients with alopecia plus other symptoms of hyperandrogenism including acne, hirsutism, and menstrual cycle disturbances (group B, n = 77). Mean serum 5alpha-androstane-3alpha,17beta-diol glucuronide (3alpha-AdiolG) levels in all three patient groups (6.50+/-4.10, 8.90+/-5.80, and 14.70+/-8.90 nmol/l, respectively) correlated with the grade of alopecia (I-III) and were significantly higher than in the control group (4.80+/-2.05 nmol/l, P < 0.005). Mean serum sex hormone-binding globulin (SHBG) levels were inversely correlated with the grade of alopecia (I-III) and were significantly lower in all three patient groups (50.55+/-23.50, 40.00+/-17.65, and 38.80+/-14.10 nmol/l, respectively) than in the control group (61.15+/-17.65 nmol/l, P < 0.05). Mean serum levels of delta4-androstenedione, dehydroepiandrosterone, dehydroepiandrosterone sulfate, and 3alpha-AdiolG were higher in group B than in group A, and higher in group A than in the control group. The significant correlations found between adrenal secretion - either positive (with 3alpha-AdiolG levels and the body mass index) or negative (with SHBG levels) - might reflect the important contribution of secretory and metabolic components in the development of alopecia, the severity of which has been shown to be very closely related to observed levels of two of these parameters (3alpha-AdiolG and SHBG).
被引量：8 发表：2000
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Polymorphisms in inflammation genes (angiotensinogen, TAP1 and TNF-beta) in psoriasis.
:This study focused on the association between plaque psoriasis and polymorphisms of several inflammation genes. Included in the study were 142 Caucasian (Czech) patients with plaque psoriasis and 141 healthy subjects. The genotypes of the polymorphisms in angiotensinogen [M235T ATG, A(-6)G ATG], in transporters associated with antigen processing TAP1 (TAP1*0101, TAP*02011 and TAP1*0301) and in lymphotoxin alpha (TNFbeta) (NcoI in intron 1) were detected by polymerase chain reaction-based methods and restriction enzyme analysis. An increase in B1 (less frequent) allele of NcoI TNFbeta polymorphism was found in psoriatic patients compared to healthy individuals (odds ratio = 1.6, 95% confidence interval 1.13-2.26, P = 0.006). A positive family history of psoriasis was associated with a higher B1 allele frequency in NcoI TNFbeta (P = 0.011). Hardy-Weinberg disequilibrium was found in TAP1 polymorphism A-->G at nucleotide 1207 in psoriatic patients. A case-control difference was found in the allelic concurrence of M235T and A(-6)G ATG polymorphisms. The most frequent population genotypes MMGG, MTAG and TTAA were observed in 92% of patients vs 74% of control subjects (odds ratio 0.29, 95% confidence interval 0.14-0.60, P = 0.0003). A positive history of tonsillitis and/or tonsillectomy was associated with a higher T allele frequency of the M235T ATG polymorphism (P = 0.037) as well as with a higher G allele frequency of the A(-6)G ATG polymorphism (P = 0.022). Polymorphisms in proinflammatory angiotensinogen and TNFbeta genes were associated with plaque psoriasis, a positive family history of psoriasis and with frequent tonsillitis in childhood.
被引量：4 发表：2000
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Distribution and potential biologic function of the thrombin receptor PAR-1 on human keratinocytes.
:Thrombin has recently been shown not only to exert procoagulant activities, but also to induce mitogenic responses of different cell types involved in wound healing via binding to and cleavage of the thrombin receptor. In order to further explore these aspects of thrombin function, human keratinocytes (HaCaT cell line) were examined for their potential mitogenic responsiveness to thrombin and for the dependency of this process on the expression of the high-affinity thrombin receptor. Quiescent keratinocytes were stimulated in the mitogenic assay with alpha-thrombin and the thrombin receptor activating peptides TRAP42-55 (SFLLRNPNDKYEPY) and TRAP42-46 (SFLLR). A strong induction of cell proliferation was noted with alpha-thrombin, TRAP42-55 and TRAP42-46, but not with the "scrambled" peptide (FSLLR). These findings confirm that keratinocytes express the thrombin receptor and that the sequence of the first two amino acids of the generated neo-N-terminus are important for the activation of the receptor. Using cDNA fragments of the 5' coding sequence of the receptor, Northern blot analysis confirmed that HaCaT keratinocytes express the thrombin receptor. Expression of the receptor was also detected on normal human keratinocytes by immunohistochemistry and in situ hybridization. These data demonstrate the expression and biologic function of the human thrombin receptor on human keratinocytes, suggesting that thrombin, among other mediators, plays an important part in the orchestration of epidermal growth and repair processes.
被引量：4 发表：2000
