自引率: 7.3%
被引量: 5073
通过率: 暂无数据
审稿周期: 暂无数据
版面费用: 暂无数据
国人发稿量: 9
投稿须知/期刊简介:
Avian Pathology is a leading journal that has the aim of disseminating knowledge concerned with the entire field of research on infectious and non-infectious diseases of poultry and all other birds. Original research is published in the form of full papers, short communications and case reports. Subject areas include pathology, immune responses, vaccines, genetics e.g. in relation to disease resistance/susceptibility, epidemiology, diagnosis, detection and characterization of pathogens, gene sequences, and physiology and biochemistry (provided that the physiological and biochemical data refer to disease). Authoritative Reviews, Commentary Articles on topical subjects and Technical Reviews (detection and differentiation of pathogens) are published from time to time.
-
The Salmonella pathogenicity island 1 and Salmonella pathogenicity island 2 type III secretion systems play a major role in pathogenesis of systemic disease and gastrointestinal tract colonization of Salmonella enterica serovar Typhimurium in the chicken.
Salmonella enterica serovar Typhimurium infection of chickens is a major public and animal health problem. In young chicks, S. Typhimurium infection results in severe systemic infection; in older chicks, infection results in prolonged gastrointestinal tract colonization. Here we determined the role of the Salmonella pathogenicity island 1 (SPI-1) and Salmonella pathogenicity island 2 (SPI-2) type III secretion systems in systemic infection and gastrointestinal tract colonization of the chicken though experimental infection of chicks with a S. Typhimurium strain with mutations in the genes encoding the secretion system machinery of SPI-1 (spaS) and SPI-2 (ssaU) that prevent secretion of effector proteins. In 1-day-old chicks, mutation of SPI-2 lead to a decrease in both systemic bacterial numbers and pathology, although no difference in gastrointestinal numbers was observed. Mutation of SPI-1 had little effect in 1-day old chicks. In 1-week-old animals the SPI-2 mutants could not be detected systemically and colonized the gastrointestinal tract only in low numbers in comparison with the parent strain, and was cleared in 1 week. The SPI-1 mutant showed greatly reduced levels of systemic infection, and colonized the gastrointestinal tract at a lower level than the parent strain. The findings show that the SPI-2 type III secretion system is required for systemic S. Typhimurium infection in both infection models, and that it plays a significant role in gastrointestinal colonization. The SPI-1 system is involved in both systemic infection and gastrointestinal colonization, but does not appear absolutely essential for either infection process.
被引量：31 发表：2007
-
Salmonella enterica serovar Pullorum requires the Salmonella pathogenicity island 2 type III secretion system for virulence and carriage in the chicken.
Functional mutations were made in the type III secretion systems encoded by Salmonella pathogenicity island 1 (SPI 1) and Salmonella pathogenicity island 2 (SPI 2) of Salmonella enterica serovar Pullorum, the cause of pullorum disease in poultry. Their role in cell invasion in vitro, and in virulence in vivo was determined. The SPI 1 mutant showed decreased invasiveness for chicken cells but was capable of causing disease in orally infected 1-day-old chicks, although it showed some reduction in virulence. The SPI 2 mutant showed no reduction in invasiveness, but was fully attenuated for virulence in 1-day-old chicks, and was not detected following oral infection in 1-week-old chickens. Following intravenous infection, the SPI 2 mutant was also attenuated and cleared more rapidly than the parent strain. This indicates that S. Pullorum requires SPI 2 for virulence and persistence but SPI 1 appears to contribute to, but is not essential for, the virulence of S. Pullorum.
被引量：24 发表：2002
