自引率: 1.3%
被引量: 4094
通过率: 暂无数据
审稿周期: 3
版面费用: 暂无数据
国人发稿量: 232
投稿须知/期刊简介:
The journal publishes original research findings (and reviews solicited by the Editor) on the subject of the identification of markers associated with the disease processes whether or not they are an integral part of the pathological lesion. The disease markers may be a genetic host factor predisposing to the disease or the occurrence of cell-surface markers, enzymes or other components, either in altered forms, abnormal concentrations or with abnormal tissue distribution. This journal is designed to provide a forum for publications dealing with original observations in this developing field on any aspect of the general topic including: Identification of new genetic or non-genetic markers (e.g., cell-surface antigens, serum proteins, intra- and extra-cellular enzymes, cytogenic markers and DNA-sequences); Population studies of new and existing markers, designed to elucidate information on their normal distribution as well as that in disease states; Amplification of knowledge about existing markers; Family studies of markers in disease; New techniques for identification and/or isolation of important marker molecules; Use of monoclonal antibodies for the definition of molecular structures associated with disease markers; Identification of disease-associated abnormalities in DNA using recombinant DNA techniques, gene-cloning and DNA restriction enzyme fragment polymorphisms; Identification of markers identifying malignantly transformed neoplastic cells.
期刊描述简介:
The journal publishes original research findings (and reviews solicited by the Editor) on the subject of the identification of markers associated with the disease processes whether or not they are an integral part of the pathological lesion. The disease markers may be a genetic host factor predisposing to the disease or the occurrence of cell-surface markers, enzymes or other components, either in altered forms, abnormal concentrations or with abnormal tissue distribution. This journal is designed to provide a forum for publications dealing with original observations in this developing field on any aspect of the general topic including: Identification of new genetic or non-genetic markers (e.g., cell-surface antigens, serum proteins, intra- and extra-cellular enzymes, cytogenic markers and DNA-sequences); Population studies of new and existing markers, designed to elucidate information on their normal distribution as well as that in disease states; Amplification of knowledge about existing markers; Family studies of markers in disease; New techniques for identification and/or isolation of important marker molecules; Use of monoclonal antibodies for the definition of molecular structures associated with disease markers; Identification of disease-associated abnormalities in DNA using recombinant DNA techniques, gene-cloning and DNA restriction enzyme fragment polymorphisms; Identification of markers identifying malignantly transformed neoplastic cells
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MicroRNA-146: Biomarker and Mediator of Cardiovascular Disease.
被引量：1 发表：1970
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Identification of Inflammatory Gene in the Congenital Heart Surgery Patients following Cardiopulmonary Bypass via the Way of WGCNA and Machine Learning Algorithms.
被引量：- 发表：1970
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Impact of rs599839 Polymorphism on Coronary Artery Disease Risk in Saudi Diabetic Patients.
Coronary artery diseases may be affected by several genetic and nongenetic factors. Single-nucleotide polymorphism (SNP) rs599839 and type 2 diabetes mellitus (T2DM) can affect the occurrence and severity of coronary artery disease (CAD). Our aim was to investigate how T2DM and the rs599839 variant affected serum lipid levels and the degree of CAD patients' coronary artery stenosis. rs599839 polymorphism genotyping was done on Saudi patients with coronary angiography performed previously. Patients enrolled were divided into group A (360 DM patients), group B (225 DM patients with CAD), and group C (190 healthy volunteers as control). Individuals with diabetes and CAD who possessed the GG genotype in rs599839 exhibited markedly reduced means of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and triglycerides (TG; 224.5, 116.2, and 221.4 versus 251.6, 131.3, and 261.7 mg/dl, p=0.003, 0.007, and 0.025, respectively) than AA genotype. The odds ratio and the confidence interval of 95% for G allele carriers of rs599839 were OR = 0.62, 95% CI: 0.41-0.82, and p=0.003, among diabetic patients with CAD. In patients with diabetic CAD, the locus 1p13.3 polymorphism rs599839 was found to be substantially correlated with serum lipid levels. Furthermore, among Saudi patients with diabetes, the G allele of rs599839 variant lowers the CAD risk.
被引量：- 发表：1970
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Assessment of Antioxidant Enzyme Superoxide Dismutase (SOD) in Oral Cancer: Systematic Review and Meta-Analysis.
The present article aims to comprehensively review the existing literature on superoxide dismutase (SOD) levels, an antioxidant enzyme, in oral cancer. An extensive literature search was conducted across various databases, including PubMed, Wiley Online Library, Science Direct, and Cross Reference, spanning 1998-2023. At the outset, 1,177 articles were initially identified, and 907 studies were excluded due to irrelevance or duplication of the research question. Subsequently, 270 articles underwent screening evaluation, resulting in the selection of 85 articles meeting the inclusion criteria. Following this, 68 articles underwent a full-text comprehensive assessment, and ultimately, 39 were chosen for data extraction. The risk of bias in the designated articles was assessed using the Newcastle-Ottawa Scale. Finally, 13 studies were meticulously selected, offering consistent data for the ensuing meta-analysis. Meta-analysis was executed using comprehensive meta-analysis (CMA) version 3 software (Bio Stat Inc., Englewood, NJ, USA). The meta-analysis findings revealed a statistically significant decrease in SOD levels in both erythrocyte samples (P < 0.001) and tissue samples (P < 0.05) among individuals with oral cancer (OSCC) compared to the normal control group. Conversely, the analysis of three studies on salivary samples demonstrated a significant increase (P < 0.05) in SOD levels in the oral cancer group compared to the healthy controls. This systematic review underscores a statistically significant decline in SOD levels observed across diverse bio-samples in individuals with oral cancer, indicating an excess of oxidative stress (OS). Additional research is needed to delve into the relationship between SOD levels and clinic-pathological prognostic markers within the oral cancer cohort. Such investigations have the potential to significantly contribute to the development of prognostic tools grounded in OS, thereby guiding strategies for treatment planning.
被引量：1 发表：1970
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Examining the Association of Rare Allelic Variants in Urate Transporters SLC22A11, SLC22A13, and SLC17A1 with Hyperuricemia and Gout.
被引量：- 发表：1970
