
自引率: 3.1%
被引量: 4732
通过率: 暂无数据
审稿周期: 1.57
版面费用: 暂无数据
国人发稿量: 131
投稿须知/期刊简介:
Cellular and Molecular Neurobiology publishes original research concerned with the analysis of neuronal and brain function at the cellular and subcellular levels. This superb bimonthly offers timely peer-reviewed articles that describe anatomic genetic physiologic pharmacologic and biochemical approaches to the study of neuronal function and the analysis of elementary mechanisms. Studies are presented on isolated mammalian tissues and intact animals with investigations aimed at the molecular mechanisms or neuronal responses at the level of single cells. The journal also presents studies of the effects of neurons on other organ systems such as analysis of the electrical or biochemical response to neurotransmitters or neurohormones on smooth muscle or gland cells. All articles are rigorously appraised by at least two referees.
期刊描述简介:
Cellular and Molecular Neurobiology publishes original research concerned with the analysis of neuronal and brain function at the cellular and subcellular levels. This superb bimonthly offers timely peer-reviewed articles that describe anatomic genetic physiologic pharmacologic and biochemical approaches to the study of neuronal function and the analysis of elementary mechanisms. Studies are presented on isolated mammalian tissues and intact animals with investigations aimed at the molecular mechanisms or neuronal responses at the level of single cells. The journal also presents studies of the effects of neurons on other organ systems such as analysis of the electrical or biochemical response to neurotransmitters or neurohormones on smooth muscle or gland cells. All articles are rigorously appraised by at least two referees.
-
Clinical Insights on Caloric Restriction Mimetics for Mitigating Brain Aging and Related Neurodegeneration.
Aging, an inevitable physiological process leading to a progressive decline in bodily functions, has been an abundantly researched domain with studies attempting to slow it down and reduce its debilitating effects. Investigations into the cellular and molecular pathways associated with aging have allowed the formulation of therapeutic strategies. Of these, caloric restriction (CR) has been implicated for its role in promoting healthy aging by modulating key molecular targets like Insulin/IGF-1, mTOR, and sirtuins. However, CR requires dedication and commitment to a strict regimen which poses a difficulty in maintaining consistency. To maneuver around cumbersome diets, Caloric Restriction Mimetics (CRMs) have emerged as promising alternatives by mimicking the beneficial effects of CR. This review elucidates the molecular foundations enabling CRMs like rapamycin, metformin, resveratrol, spermidine, and many more to function as suitable anti-aging molecules. Moreover, it explores clinical trials (retrieved from the clinicaltrials.gov database) aimed at demonstrating the efficacy of CRMs as effective candidates against age-related neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease.
被引量:- 发表:1970
-
Correction: Upregulation of miR-107 Inhibits Glioma Angiogenesis and VEGF Expression.
被引量:- 发表:1970
-
Application of Optogenetics in Neurodegenerative Diseases.
被引量:- 发表:1970
-
Extracellular Matrix Structure and Interaction with Immune Cells in Adult Astrocytic Tumors.
被引量:- 发表:1970
-
Therapeutic Implications and Regulations of Protein Post-translational Modifications in Parkinsons Disease.
被引量:- 发表:1970