
自引率: 5.7%
被引量: 20329
通过率: 暂无数据
审稿周期: 1.94
版面费用: 27020
国人发稿量: 8
投稿须知/期刊简介:
Breast Cancer Research and Treatment provides the surgeon radiotherapist medical oncologist endocrinologist epidemiologist immunologist or cell biologist investigating problems in breast cancer a single forum for communication. The journal creates a 'market place' for breast cancer topics which cuts across all the usual lines of disciplines providing a site for presenting pertinent investigations and for discussing critical questions relevant to the entire field. It seeks to develop a new focus and new perspectives for all those concerned with breast cancer. Oncology is undoubtedly the most rapidly growing subspecialty in the field of medicine and breast cancer is one of the most serious problems of oncology. It is the leading cause of death of women in many countries and is truly a multidisiplinary problem without geographic restrictions. Yet this very multidisciplinary aspect accounts for breast cancer literature appearing in any of the dozens of existing medical journals. None of these journals provides a focus on the unique problems of breast cancer. There has been no convenient arena for the discussion and resolution of ongoing controversies in breast cancer treatment or for the consideration of thoughtful speculation and comments on current work. Breast Cancer Research and Treatment aims to fill this need. Each issue contains several articles dealing with original laboratory investigations and articles dealing with clinical studies. There are sections devoted to invited review articles pro and con discussions of controversial subjects book reviews meeting reports and editorials. Panel discussions are presented which bring together experts to consider important topics. There is a section for letters to the editor which provides for a lively exchange of opinions on previously published articles or other topics of interest. There is also an opportunity to publish the proceedings of special workshops symposia etc. devoted to breast cancer. All manuscripts are peer reviewed by a distinguished group of advisory editors from many countries covering all of the various disciplines of breast cancer.
期刊描述简介:
Breast Cancer Research and Treatment provides the surgeon radiotherapist medical oncologist endocrinologist epidemiologist immunologist or cell biologist investigating problems in breast cancer a single forum for communication. The journal creates a 'market place' for breast cancer topics which cuts across all the usual lines of disciplines providing a site for presenting pertinent investigations and for discussing critical questions relevant to the entire field. It seeks to develop a new focus and new perspectives for all those concerned with breast cancer. Oncology is undoubtedly the most rapidly growing subspecialty in the field of medicine and breast cancer is one of the most serious problems of oncology. It is the leading cause of death of women in many countries and is truly a multidisiplinary problem without geographic restrictions. Yet this very multidisciplinary aspect accounts for breast cancer literature appearing in any of the dozens of existing medical journals. None of these journals provides a focus on the unique problems of breast cancer. There has been no convenient arena for the discussion and resolution of ongoing controversies in breast cancer treatment or for the consideration of thoughtful speculation and comments on current work. Breast Cancer Research and Treatment aims to fill this need. Each issue contains several articles dealing with original laboratory investigations and articles dealing with clinical studies. There are sections devoted to invited review articles pro and con discussions of controversial subjects book reviews meeting reports and editorials. Panel discussions are presented which bring together experts to consider important topics. There is a section for letters to the editor which provides for a lively exchange of opinions on previously published articles or other topics of interest. There is also an opportunity to publish the proceedings of special workshops symposia etc. devoted to breast cancer. All manuscripts are peer reviewed by a distinguished group of advisory editors from many countries covering all of the various disciplines of breast cancer.
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Hypoxia inducible factor-1alpha correlates with VEGF-C expression and lymphangiogenesis in breast cancer.
The transcription factor Hypoxia inducible factor-1alpha (HIF-1alpha) plays a crucial role in tumor progression by regulating angiogenesis, cell survival and drug resistance. HIF-1alpha is also implicated in biological functions under normoxic conditions and recent data provide evidence for a possible role in tumor lymphangiogenesis by regulating the lymphatic vascular endothelial growth factor-C (VEGF-C). In breast cancer, lymphatic vessel invasion (LVI) by tumor cells and subsequent metastasis to axillary lymph nodes is a critical point in progression of the disease with severe therapeutical and prognostic implications. Aim of this study is to investigate the role of HIF-1alpha in VEGF-C expression, lymphangiogenesis, and LVI in lymph node positive breast cancer. Lymphatic microvessel density (LMVD), LVI, HIF-1alpha and VEGF-C protein-expression were evaluated by immunohistochemistry in 119 cases of lymph node positive invasive breast cancer. There was a significant correlation between HIF-1alpha and VEGF-C (p = 0.026, r = 0.204, Spearman's coefficient of correlation). Further a significant association between HIF-1alpha-expression and the amount of peritumoral lymphangiogenesis LMVD was seen (p = 0.014, Mann-Whitney test). LMVD correlated significantly with LVI (p<0.001, Mann-Whitney test). HIF-1alpha was an independent prognostic factor for overall and disease free survival in uni- and multivariate analysis (p = 0.027, 0.029, 0.025, respectively, Cox regression). Our data provide evidence for a possible role of HIF-1alpha as regulator of tumor-associated lymphangiogenesis in human breast cancer and emphasizes the promising status of HIF-1alpha as a therapeutical target against tumor progression and metastasis.
被引量:- 发表:1970