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投稿须知/期刊简介:
Brain Research Reviews is a special section of Brain Research which provides a medium for prompt publication of review articles and, occasionally, long research papers with extensive review components, which give analytical surveys that define heuristic hypotheses and provide new insights into brain mechanisms.TYPES OF PAPERS 1. Reviews. In principle, there is no limit to the length of reviews published in the journal. 2. Interactive Reviews are reviews that are considered worthy of priority publication. These will appear in electronic form on the Brain Research Interactive website (http://www.bres-interactive.com) before being published in the print journal. The on-line version may include additional data sets, 3-D/confocal images, animations, etc., and be linked to relevant on-line databases. Comments from readers may be appended later in a linked Discussion Forum at the discretion of an appointed Moderator.
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Dynamin-related protein 1 and mitochondrial fragmentation in neurodegenerative diseases.
The purpose of this article is to review the recent developments of abnormal mitochondrial dynamics, mitochondrial fragmentation, and neuronal damage in neurodegenerative diseases, including Alzheimer's, Parkinson's, Huntington's, and amyotrophic lateral sclerosis. The GTPase family of proteins, including fission proteins, dynamin related protein 1 (Drp1), mitochondrial fission 1 (Fis1), and fusion proteins (Mfn1, Mfn2 and Opa1) are essential to maintain mitochondrial fission and fusion balance, and to provide necessary adenosine triphosphate to neurons. Among these, Drp1 is involved in several important aspects of mitochondria, including shape, size, distribution, remodeling, and maintenance of mitochondria in mammalian cells. In addition, recent advancements in molecular, cellular, electron microscopy, and confocal imaging studies revealed that Drp1 is associated with several cellular functions, including mitochondrial and peroxisomal fragmentation, phosphorylation, SUMOylation, ubiquitination, and cell death. In the last two decades, tremendous progress has been made in researching mitochondrial dynamics, in yeast, worms, and mammalian cells; and this research has provided evidence linking Drp1 to neurodegenerative diseases. Researchers in the neurodegenerative disease field are beginning to recognize the possible involvement of Drp1 in causing mitochondrial fragmentation and abnormal mitochondrial dynamics in neurodegenerative diseases. This article summarizes research findings relating Drp1 to mitochondrial fission and fusion, in yeast, worms, and mammals. Based on findings from the Reddy laboratory and others', we propose that mutant proteins of neurodegenerative diseases, including AD, PD, HD, and ALS, interact with Drp1, activate mitochondrial fission machinery, fragment mitochondria excessively, and impair mitochondrial transport and mitochondrial dynamics, ultimately causing mitochondrial dysfunction and neuronal damage.
被引量：- 发表：1970
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Targeting CB2 receptors and the endocannabinoid system for the treatment of pain.
被引量：84 发表：1970
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Metabotropic receptors for glutamate and GABA in pain.
被引量：77 发表：1970
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Cholinergic modulation of midbrain dopaminergic systems.
被引量：68 发表：1970
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The spinal pattern generator for ejaculation.
被引量：19 发表：1970
