自引率: 18.7%
被引量: 9564
通过率: 暂无数据
审稿周期: 3
版面费用: 暂无数据
国人发稿量: 186
投稿须知/期刊简介:
Developmental and Comparative Immunology (DCI) is an international journal that publishes articles describing original research in the areas of development of the immune system and comparative immunology. Manuscripts describing studies dealing with self/nonself discrimination in nontraditional vertebrate and invertebrate models are welcome. All levels of immunological investigation are appropriate: organismal, cellular, biochemical, and molecular genetics, extending to such fields as aging of the immune system and interactions between the immune and neuroendocrine systems. Developmental and Comparative Immunology will publish full-length research articles and brief communications.
期刊描述简介:
The Official Journal of the International Society of Developmental and Comparative Immunology Developmental and Comparative Immunology (DCI) is an international journal that publishes articles describing original research in all areas of immunology, including comparative aspects of immunity and the evolution and development of the immune system. Manuscripts describing studies of immune systems in both vertebrates and invertebrates are welcome. All levels of immunological investigations are appropriate: organismal, cellular, biochemical and molecular genetics, extending to such fields as aging of the immune system, interaction between the immune and neuroendocrine system and intestinal immunity.
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Phagocyte dynamics in the blastogenetic cycle of the colonial ascidian Botryllus schlosseri: Cell senescence, segregation and clearance after efferocytosis.
被引量：- 发表：1970
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Integrated microRNA study and pathological analysis provides new insights into the immune response of Ruditapes philippinarum under Vibrio anguillarum challenge.
被引量：- 发表：1970
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Oral administration enhances directly mucosal immune system in intestine of olive flounder (Paralichthys olivaceus).
被引量：- 发表：1970
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First report of a chemokine from camelids: Dromedary CXCL8 is induced by poxvirus and heavy metal toxicity.
Low molecular weight proteins, known as chemokines, facilitate the migration and localization of immune cells to the site of infection and injury. One of the first chemokines identified, CXCL8 functions as a key neutrophil activator, recruiting neutrophils to sites of inflammation. Several viral infections, including zoonotic coronaviruses and poxviruses, have been reported to induce the expression of CXCL8. Dromedary camels are known to harbor several potentially zoonotic pathogens, but critical immune molecules such as chemokines remain unidentified. We report here the identification of CXCL8 from the dromedary camel - the first chemokine identified from camelids. The complete dromedary CXCL8 cDNA sequence as well as the corresponding gene sequence from dromedary and two New World camelids - alpaca and llama were cloned. CXCL8 mRNA expression was relatively higher in PBMC, spleen, lung, intestine, and liver. Poly(I:C) and lipopolysaccharide stimulated CXCL8 expression in vitro, while interferon treatment inhibited it. In vitro infection with potentially zoonotic camelpox virus induced the expression of CXCL8 in camel kidney cells. Toxicological studies on camelids have been limited, and no biomarkers have been identified. Hence, we also evaluated CXCL8 mRNA expression as a potential biomarker to assess heavy metal toxicity in camel kidney cells in vitro. CXCL8 expression was increased after in vitro exposure to heavy metal compounds of cobalt and cadmium, suggesting potential utility as a biomarker for renal toxicity in camels. The results of our study demonstrate that camel CXCL8 plays a significant role in immunomodulatory and induced toxicity responses in dromedary camels.
被引量：- 发表：1970
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Enhancement of immunity and disease resistance in Litopenaeus vannamei through injection of tyramine formulated with polyethylene glycol.
被引量：- 发表：1970
