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Clinical and Laboratory Haematology is an international journal providing a forum for the communication of new developments, research topics and the practice of clinical and laboratory haematology. The journal publishes: invited reviews; full length original articles; case reports; technical reports; regular book reviews; notices and correspondence. In addition, the Journal publishes Synoptics, an occasional review series presenting a written summary of meetings which readers might have missed. An active and positive editorial policy ensures that work of the highest scientific standard is reported, promoting effective communication amongst practising haematologists.
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The initial phase of graft-versus-host disease is associated with a decrease of CD4+CD25+ regulatory T cells in the peripheral blood of patients after allogeneic stem cell transplantation.
被引量：8 发表：2006
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Hydroxyurea therapy increases plasma erythropoietin in patients with essential thrombocythaemia or polycythaemia vera.
被引量：2 发表：2006
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Thrombotic thrombocytopenic purpura in southern Turkey: a single-center experience of 29 cases.
被引量：3 发表：2005
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Quantitative nested reverse transcriptase PCR vs. real-time PCR for measuring AML1/ETO (MTG8) transcripts.
被引量：- 发表：2004
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Variation in inhibitor reactivity in acquired haemophilia A with different concentrates.
:Acquired haemophilia A due to the development of auto-antibodies directed against factor VIII (FVIII) is a rare disorder that may result in serious haemorrhagic episodes. Although in many cases no associated underlying disorders are apparent, the condition has been reported in association with autoimmune disorders, haematological malignancies, treatment with certain drugs and pregnancy. The reaction kinetics of auto-antibodies to FVIII differ from those observed with allo-antibodies in congenital haemophilia. Previous studies in congenital haemophilia have raised the possibility that inhibitory antibodies vary in their reactivity with the factor VIII molecules in different concentrates used for treatment. However, the interaction of FVIII in concentrates and inhibitors in acquired haemophilia has never been previously studied. In this study, the effect of different FVIII concentrates was studied on neutralization in vitro by performing inhibitor titres using the New Oxford inhibitor assay method. The inhibitor titre in eight patients with acquired haemophilia A was assayed against five commercially available FVIII concentrates of varying purity. The intermediate purity concentrate 8Y and the high purity concentrate that contains normal amounts of von Willebrand's Factor (vWF) (Alphanate) gave lower titres than the high purity concentrates with low (Monoclate-P) or no (Kogenate) von Willebrand content. All but one antibody had very low reactivity with porcine FVIII. Further work will be required to establish whether concentrates manifesting a low level of in vitro reactivity with the inhibitor have a better haemostatic effect in vivo.
被引量：3 发表：2000
