自引率: 10.5%
被引量: 11951
通过率: 暂无数据
审稿周期: 2.75
版面费用: 暂无数据
国人发稿量: 104
投稿须知/期刊简介:
An Official Publication of the Transplantation Society, The Japan Society for Transplantation, The Hellenic Transplantation Society, The European Society for Transplantation, The Canadian Transplantation Society, The Transplantation Society of Australia and New Zealand, The Scandinavian Transplantation Society, The Latin American Transplantation Society, The Pan-American Society for Dialysis & Transplantation, The Society for Organ Sharing, The Catalan Transplantation Society, The Asian Transplantation Society, The International Liver Transplant Society, The Cell Transplant Society, The Middle East Society for Organ Transplantation, Société Française de Transplantation, Israel Transplantation Society, International Pancreas and Islet Transplant Association, Polish Transplantation Society, The Malaysian Transplantation Society, The Turkish Transplantation Society Transplantation Proceedings publishes several different categories of manuscripts, all of which undergo extensive peer review by recognized authorities in the field prior to their acceptance for publication. The first type of manuscripts consists of sets of papers providing an in-depth expression of the current state of the art in various rapidly developing components of world transplantation biology and medicine. These manuscripts emanate from the International Congresses of the Transplantation Society, from the Affiliated Societies, from Symposia sponsored by the Societies, and special Conferences and Workshops covering related topics. Transplantation Proceedings also publishes several special sections, including Transplantatio Japonica and Clinical Transplantation Proceedings.
期刊描述简介:
Transplantation Proceedings publishes several different categories of manuscripts, all of which undergo extensive peer review by recognized authorities in the field prior to their acceptance for publication. The first type of manuscripts consists of sets of papers providing an in-depth expression of the current state of the art in various rapidly developing components of world transplantation biology and medicine. These manuscripts emanate from congresses of the affiliated transplantation societies, from Symposia sponsored by the Societies, as well as special Conferences and Workshops covering related topics. Transplantation Proceedings also publishes several special sections including publication of Clinical Transplantation Proceedings, being rapid original contributions of preclinical and clinical experiences. These manuscripts undergo review by members of the Editorial Board.
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Alleviating ischemia-reperfusion injury in aged rat liver by induction of heme oxygenase-1.
Heme oxygenase-1 (HO-1), a cytoprotective protein, may be important in ameliorating hepatic ischemia-reperfusion (I/R) injury, a critical factor in the dysfunction of the aged liver after transplantation. We used hemin to overexpress HO-1 and analyze its effects in a model of I/R in aged livers used for orthotopic transplantation. The SGOT levels in the hemin group were significantly lower than those of the saline treatment group. Hemin liver grafts showed markedly fewer apoptotic (TUNEL+) liver cells after reperfusion compared with the controls. The plasma nitric oxide levels in the hemin group were significantly lower than those in the control group. Unlike untreated or hemin + Znpp-treated orthotopic liver transplant controls, iNOS expression in the hemin group was almost absent at 12 and 24 hours, after reperfusion. In contrast, eNOS was comparable in hemin and saline orthotopic liver transplants. The increased levels of Bcl-2 expression compared with saline controls were most pronounced at 12 hours after transplantation. In contrast, caspase 3 was lower at 24 hours among the hemin-pretreated group compared with saline-treated liver transplant controls. HO-1 alleviated the I/R injury in the aged liver by suppressing local expression of inducible nitric oxide synthase and by modulating pro- and antiapoptotic pathways.
被引量：- 发表：2004
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Infusion of in vitro-generated DN T regulatory cells induces permanent cardiac allograft survival in mice.
Previously, we have demonstrated that pretransplant donor lymphocyte infusion (DLI) can activate recipient-derived CD3+CD4-CD8- double negative T regulatory (DN Tr) cells which have a potent immune regulatory function in vitro and in vivo. Here we studied the regulatory ability of DN T cell clones generated from the spleens of nai;ve anti-L(d) transgenic TCR+ (2C x dm2)F1 mice. We were able to identify subsets of DN T cell clones that were able to kill anti-Ld CD8+ T cells, and therefore had regulatory properties, and DN T cells with no regulatory properties. Next, we investigated the ability of these in vitro generated DN T cell clones to enhance cardiac allograft survival. (2C x dm2)F1 transgenic mice were infused with either regulatory or non-regulatory DN T cell clones, or left untreated one day before receiving an Ld-mismatched cardiac grafts from (C57BL/6 x Balb/c)F1 mice. Injection of non-regulatory DN T clone cells did not prolong cardiac graft survival in (2C x dm2)F1 mice when compare to untreated controls. In contrast, all of the cardiac grafts survived more than 100 days in mice that received DN Tr clone cells prior to transplantation. These results demonstrate that DN Tr cells can be generated in vitro and protect cardiac allograft from rejection when infused into recipients prior to transplantation. They also suggest that DN Tr cells may provide a novel therapy for the treatment of allograft rejection.
被引量：- 发表：2003
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Heme oxygenase-1 gene transfer prevents CD95/FasL-mediated apoptosis and improves liver allograft survival via carbon monoxide signaling pathway.
被引量：2 发表：2002
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Heme oxygenase-1 gene therapy: a novel immunomodulatory approach in liver allograft recipients?
被引量：- 发表：2001
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Delayed xenograft rejection in C3-depleted discordant (pig-to-baboon) cardiac xenografts treated with cobra venom factor.
被引量：2 发表：1996
