自引率: 3.3%
被引量: 18958
通过率: 暂无数据
审稿周期: 2.31
版面费用: 暂无数据
国人发稿量: 146
投稿须知/期刊简介:
Toxicology and Applied Pharmacology publishes original scientific research pertaining to action on tissue structure or function resulting from administration of chemicals, drugs, or natural products to animals or humans. Articles address mechanistic approaches to physiological, biochemical, cellular, or molecular understanding of toxicologic/pathologic lesions and to methods used to describe these responses. Papers concerned with alternatives to the use of experimental animals are encouraged.
期刊描述简介:
Toxicology and Applied Pharmacology publishes original scientific research pertaining to action on tissue structure or function resulting from administration of chemicals, drugs, or natural products to animals or humans. Articles address mechanistic approaches to physiological, biochemical, cellular, or molecular understanding of toxicologic/pathologic lesions and to methods used to describe these responses. Papers concerned with alternatives to the use of experimental animals are encouraged.
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Protective effect of hydroxysafflor yellow a on thioacetamide-induced liver injury and osteopenia in zebrafish.
被引量：- 发表：1970
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The downregulation of TREM2 exacerbates toxicity of development and neurobehavior induced by aluminum chloride and nano-alumina in adult zebrafish.
被引量：- 发表：1970
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From computational prediction to experimental validation: Hesperidin's anti-Urolithiatic activity in sodium oxalate-induced urolithiasis models in fruit flies and mice.
被引量：- 发表：1970
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Corrigendum to "Effects of a spiroketal compound Peniciketal A and its molecular mechanisms on growth inhibition in human leukemia" [Toxicology and Applied Pharmacology, 2019, 1:366:1-9].
被引量：- 发表：1970
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Ferulic acid ameliorates concanavalin A-induced hepatic fibrosis in mice via suppressing TGF-β/smad signaling.
Hepatic fibrosis, one of the main reasons for death globally, is a serious complication of chronic liver disorders. However, the available therapies for liver fibrosis are limited, ineffective, and often associated with adverse events. Hence, seeking for a novel, effective therapy is warranted. Our objective was to investigate the potential efficacy of ferulic acid (FA), a phenolic phytochemical, at different doses in hindering the progress of concanavalin A (Con A)-induced hepatic fibrosis and explore the involved mechanisms. Thirty-six mice were assorted into 6 groups (n = 6): Group I (control); group II received FA (20 mg/kg/day orally for 4 weeks); group III received Con A (6 mg/kg/week/i.v.) for 4 weeks; groups IV, V, and VI received Con A and were offered FA at 5, 10, and 20 mg/kg/day, respectively. The data showed the palliative effect of FA against Con A-induced fibrosis in a dose-dependent manner. This was obvious from the recovery of liver markers and hepatic architecture with the regression of fibrosis in FA-treated mice. FA abolished Con A-mediated oxidative insults and promoted the antioxidant enzyme activities, which run through the Nrf2/HO-1 signaling. Additionally, FA suppressed Con A-induced increase in NF-kB and IL-β levels, and TNF-α immune-expression. The anti-fibrotic effect of FA was evident from the drop in TGF-β, smad3 levels, α-SMA expression, and hydroxyproline content. FA attenuated Con A-induced liver fibrosis through stimulating Nrf2 signaling, suppressing NF-kB, and inhibiting the TGF-β/smad3 signaling pathway. Thus FA can be considered as a promising therapy for combating liver fibrosis.
被引量：- 发表：1970
