自引率: 0.7%
被引量: 7841
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投稿须知/期刊简介:
Transactions of the Royal Society of Tropical Medicine and Hygiene publishes original, peer-reviewed articles, and invited reviews across a broad range of topics relevant to the Society's goals, including: clinical tropical medicine and case reports, infectious diseases, parasitology and entomology, microbiology and virology, epidemiology, chemotherapy, immunology, public health, including social science. A key objective is to present the results of research that are broadly intelligible to workers from a range of disciplines. We welcome articles on translational research that may impact directly on clinical and public health practice in developing countries and those describing the application of new technologies in tropical medicine.
期刊描述简介:
Transactions of the Royal Society of Tropical Medicine and Hygiene publishes original, peer-reviewed articles, and invited reviews across a broad range of topics relevant to the Society's goals, including: clinical tropical medicine and case reports, infectious diseases, parasitology and entomology, microbiology and virology, epidemiology, chemotherapy, immunology, public health, including social science. A key objective is to present the results of research that are broadly intelligible to workers from a range of disciplines. We welcome articles on translational research that may impact directly on clinical and public health practice in developing countries and those describing the application of new technologies in tropical medicine.
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An innovative ecohealth intervention for Chagas disease vector control in Yucatan, Mexico.
Non-domiciliated (intrusive) triatomine vectors remain a challenge for the sustainability of Chagas disease vector control as these triatomines are able to transiently (re-)infest houses. One of the best-characterized examples is Triatoma dimidiata from the Yucatan peninsula, Mexico, where adult insects seasonally infest houses between March and July. We focused our study on three rural villages in the state of Yucatan, Mexico, in which we performed a situation analysis as a first step before the implementation of an ecohealth (ecosystem approach to health) vector control intervention. The identification of the key determinants affecting the transient invasion of human dwellings by T. dimidiata was performed by exploring associations between bug presence and qualitative and quantitative variables describing the ecological, biological and social context of the communities. We then used a participatory action research approach for implementation and evaluation of a control strategy based on window insect screens to reduce house infestation by T. dimidiata. This ecohealth approach may represent a valuable alternative to vertically-organized insecticide spraying. Further evaluation may confirm that it is sustainable and provides effective control (in the sense of limiting infestation of human dwellings and vector/human contacts) of intrusive triatomines in the region.
被引量：31 发表：2015
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Natural infection and distribution of triatomines (Hemiptera: Reduviidae) in the state of Querétaro, Mexico.
Chagas disease is present in Mexico but data on the presence of its vectors are not known for all the states. We conducted an epidemiological study to ascertain the presence of bedbugs in 23 communities of seven municipalities in the state of Querétaro, Mexico. Sampling was performed within and outside dwellings, using the technique of one person searching per hour per house. Four triatomine species were found: Triatoma mexicana (94%), Tri. dimidiata (3%), Tri. gerstaeckeri (2%) and Tri. pallidipennis (1%). Triatoma mexicana was found in six of the seven municipalities but has previously been found only in the state of Hidalgo, where it is considered the most important vector species of Trypanosoma cruzi. This is the first time that the presence of Tri. gerstaeckeri or Tri. dimidiata has been reported in the state of Querétaro. Tolimán municipality had the highest entomological indices: infestation index 73%; infection index 34.5%; crowding index 9.2%; density index 6.7%; and colonization index 20.6%. Although the prevalence and colonization indices were low, the infestation and infection indices indicate that different Triatoma species are becoming established in Querétaro. This work represents the first entomological study in this Mexican state and suggests that some triatomine vectors are extraordinarily mobile.
被引量：6 发表：1970
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Reduction in the mean number of Plasmodium falciparum genotypes in Gambian children immunized with the malaria vaccine SPf66.
SPf66, a synthetic peptide Plasmodium falciparum vaccine, did not protect young Gambian children against clinical attacks of malaria. Nevertheless, Gambian children who had been vaccinated with SPf66 and who were parasitaemic at the end of the first malaria transmission season after vaccination had significantly fewer detectable P. falciparum genotypes than control children, as determined by polymerase chain reaction analysis of 3 polymorphic loci--the msp1 block 2 repeat region, the msp2 repeat region, and the R11 region of the glutamate-rich protein gene (glurp). Geometric mean numbers of genotypes were 1.66 vs. 1.87, 1.95 vs. 2.43, and 1.21 vs. 1.50 for msp1, msp2 and glurp, respectively (P = 0.31, P = 0.04 and P < 0.01). Differences between groups became a little more marked for msp1 and msp2 when children with symptomatic malaria were excluded. No significant difference was found between parasites obtained from SPf66-vaccinated or control children in the prevalences of amino acid alleles at positions 44 and 47 in the 11 amino acid sequence of the merozoite surface protein 1 molecule, which is present in SPf66. The reduction in the number of genotypes observed could not be explained by a difference in parasite densities between SPf66-vaccinated and control children, as geometric mean parasite densities were almost identical in the 2 groups. These observations suggest that SPf66 vaccine may have induced an immune response which reduced the incidence of new infections in immunized children or accelerated the rate of clearance of parasites of individual genotypes. However, no reduction in the prevalence or density of parasitaemia was recorded in SPf66-vaccinated children, suggesting the existence of some kind of density-dependent mechanism for controlling low levels of malaria parasitaemia.
被引量：- 发表：1999
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A comparison of Rhodnius prolixus, Triatoma infestans and Panstrongylus megistus in the xenodiagnosis of a chronic Trypanosoma (schizotrypanum) cruzi infection in a rhesus monkey (Macaca mullatta).
Fifth instar Rhodnius prolixus, Triatoma infestans and Panstrongylus megistus were fed on a rhesus monkey (Macaca mullatta) with a chronic infection of Peru strain Trypanosoma cruzi and examined 30 days later for the presence of trypanosomes in the rectum. No correlation could be demonstrated between either blood meal size or sex and the subsequent development of a rectal infection with T. cruzi. As T. infestans and P. megistus were more highly infected than R. prolixus in terms of both percentage infected and degree of infection, the two former species can be regarded as more suitable for the xenodiagnosis of this particular strain of T. cruzi in M. Mullatta.
被引量：- 发表：1975
