自引率: 4.2%
被引量: 3086
通过率: 暂无数据
审稿周期: 暂无数据
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国人发稿量: 2
投稿须知/期刊简介:
Pathology is committed to publishing peer-reviewed, original articles related to the science of pathology in its broadest sense, including chemical pathology, experimental pathology, genetics, haematology, histopathology, immunology, microbiology, molecuar pathology and morbid anatomy. Call for Papers Manuscripts to be considered for publication should be submitted to the Editor: Professor C. S. Lee, Editorial Office, Royal College of Pathologists of Australasia, Durham Hall, 207 Albion Street, Surry Hills, NSW 2010, Australia. Tel: +61 2 8356 5858; Fax: +61 2 8356 5828. All submissions will be independently judged by at least two referees. Authors should consult the ' Notes for Contributors ' before sending a manuscript.
期刊描述简介:
Pathology - Journal of the RCPA is committed to publishing peer-reviewed, original articles related to the science of pathology in its broadest sense, including anatomical pathology, chemical pathology and biochemistry, cytopathology, experimental pathology, forensic pathology and morbid anatomy, genetics, haematology, immunology and immunopathology, microbiology and molecular pathology. Published on behalf of the Royal College of Pathologists of Australasia.
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ALK-positive large B-cell lymphoma: a clinicopathological and molecular characteristics analysis of seven cases.
Anaplastic lymphoma kinase-positive large B-cell lymphoma (ALK+ LBCL) is a rare and highly aggressive lymphoma with characteristic ALK rearrangements. Various fusion genes involving ALK have been demonstrated, but the influence of the ALK fusion partners on ALK protein expression and the genetic characteristics of ALK+ LBCL remain relatively unknown. In this study, we conducted an extensive clinicopathological and molecular analysis on seven cases of ALK+ LBCL to explore the correlation between ALK fusion genes and ALK protein expression, thereby enriching the genetic characteristics of this tumour. We integrated the findings from clinical, histopathological/immunophenotypic, and molecular studies, including three samples subjected to next-generation sequencing, and six cases underwent RNA-based ALK fusion gene detection. We identified five distinct types of ALK fusion genes, including CLTC, NPM1, PABPC1, SEC31A, and TFG. Notably, only the NPM1::ALK fusion showed nuclear and cytoplasmic ALK staining, and the remaining four fusion genes resulted in cytoplasmic ALK staining. Our analysis revealed that the CLTC::ALK fusion resulted in a unique cytoplasmic perinuclear Golgi zone focal granular heterogeneous staining pattern of ALK. Additionally, we identified six potentially clinically significant gene mutations, including TET2, CHD2, DTX1, KMT2D, LRP1B, and XPO1. Furthermore, in all cases, the absence of 5-hydroxymethylcytosine (5hmC) was observed. We present seven cases of ALK+ LBCL, discussing the correlation between fusion genes and ALK protein expression, and enhancing our understanding of the genetic attributes of this tumour. This study also shows the loss of 5hmC in nearly all seven ALK+ LBCL cases, independently of TET2 mutations.
被引量：- 发表：1970
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Benign prostatic hyperplasia and insignificant prostate cancer with very high levels of serum prostate specific antigen.
被引量：- 发表：1970
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MST1R/RON fusion as a potential oncogenic driver in Spitz tumours.
被引量：- 发表：1970
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IgA deficiency in coeliac disease: verification of a cost-effective screening algorithm in a medical diagnostic laboratory.
被引量：- 发表：1970
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From the midfacial destructive drama to the unfolding EBV story: a short history of EBV-positive NK-cell and T-cell lymphoproliferative diseases.
Epstein-Barr virus (EBV) is a ubiquitous gammaherpesvirus that has been related to oncogenesis of lymphoid and epithelial malignancies. Although the mechanism of EBV infection of NK and T cells remains enigmatic, it plays a pathogenic role in various EBV+ NK-cell and T-cell lymphoproliferative diseases (LPDs), through promotion of cell activation pathways, inhibition of cell apoptotic pathways, behaving as oncogenes, interacting with host oncogenes or acting epigenetically. The study of NK-cell LPDs, previously hampered by the lack of immunophenotypical and genotypical criteria of NK cells, has become feasible with the recently accepted criteria. EBV+ NK- and T-cell LPDs are mostly of poor prognosis. This review delivers a short history from primeval to recent EBV+ NK- and T-cell LPDs in non-immunocompromised subjects, coupled with increasing interest, and work on the biological and oncogenic roles of EBV.
被引量：- 发表：1970
