自引率: 5%
被引量: 21682
通过率: 暂无数据
审稿周期: 1.62
版面费用: 暂无数据
国人发稿量: 74
投稿须知/期刊简介:
Neuropharmacology publishes monthly articles of any length (full papers, rapid communications and reviews) that fall within the discipline of neuroscience. Papers within the area of cellular and molecular neuroscience and/or that contain a significant neuropharmacological content are particularly encouraged. Papers will only be considered for publication providing they make an original and important contribution to the field of neuropharmacology. Submission to this journal is taken to imply that manuscripts have not been, and will not be submitted elsewhere until a decision has been made by the editor of Neuropharmacology. Neuronal Nicotinic Receptors - The 10th Neuropharmacology Conference - will take place November 2-4, 2000 in New Orleans, USA as an official satellite of the 2000 Meeting of the Society for Neuroscience. For full information visit the conference website.
期刊描述简介:
Neuropharmacology publishes monthly articles of any length (full papers, rapid communications and reviews) that fall within the discipline of neuroscience. Papers within the area of cellular and molecular neuroscience and/or that contain a significant neuropharmacological content are particularly encouraged. Papers will only be considered for publication providing they make an original and important contribution to the field of neuropharmacology. Submission to this journal is taken to imply that manuscripts have not been, and will not be submitted elsewhere until a decision has been made by the editor of Neuropharmacology. Neuronal Nicotinic Receptors - The 10th Neuropharmacology Conference - will take place November 2-4, 2000 in New Orleans, USA as an official satellite of the 2000 Meeting of the Society for Neuroscience. For full information visit the conference website.
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20(R)-ginsenoside Rg3 protects against focal cerebral ischemia‒reperfusion injury by suppressing autophagy via PI3K/Akt/mTOR signaling pathway.
This study aimed to investigate the effect of 20(R)-ginsenoside Rg3 on autophagy induced by cerebral ischemia‒reperfusion injury (CIRI) in rats and explore its regulation of the PI3K/Akt signaling pathway. Middle cerebral artery occlusion/reperfusion (MCAO/R) in male rats was injected intraperitoneally with 20(R)-ginsenoside Rg3 (5, 10, 20 mg/kg) 12 h before modeling, 2 h after ischemia and 12 h after reperfusion. Neurobehavioral and neuronal morphological changes were detected 24 h after brain I/R. In vitro, the OGD/R-induced injury model is replicated in PC12 cells and different concentrations of 20(R)-ginsenoside Rg3 are administered to observe its effects on cell viability and autophagy and PI3K/Akt/mTOR-related protein expression. Our findings suggest that treatment with 20 mg/kg 20(R)-ginsenoside Rg3 significantly attenuated the neuronal injury, as evidenced by a decreased number of damaged neurons, reduced dissolution of Nissl corpuscles, a fewer autophagosomes, and downregulated expression of Beclin1 and LC3-II/I compared with the MCAO/R group. Furthermore, 20(R)-ginsenoside Rg3 treatment significantly upregulated the expression of p62, p-PI3K, p-AKT, and p-mTOR. In vitro, 20(R)-ginsenoside Rg3 significantly improved the survival rate of cells following OGD/R and markedly attenuated the LY294002 and OGD/R-induced upregulation of Beclin1 and LC3 gene expression. Moreover, 20(R)-ginsenoside Rg3 could rescued the LY294002 and OGD/R-induced downregulation of p62, p-PI3K, p-AKT, and p-mTOR expression. 20(R)-ginsenoside Rg3 attenuates neuronal injury and motor dysfunction following ischemia-reperfusion by inhibiting the activation of autophagy, and its mechanism is related to the upregulation of the PI3K/Akt/mTOR signaling pathway.
被引量：- 发表：1970
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Epigenetic mechanisms of bone cancer pain.
被引量：- 发表：1970
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Flavors of GPCR signaling bias.
被引量：- 发表：1970
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Expression of sensitized β2 nAChR subunits in VTA neurons enhances intravenous nicotine self-administration in male rats.
被引量：- 发表：1970
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Nano-pregabalin effectively mitigates Glut, CGRP and NE neurotransmitters abnormalities in the brain of gamma irradiated rats with reserpine-induced fibromyalgia model: Behavioral and neurochemical studies.
被引量：- 发表：1970
