自引率: 10.8%
被引量: 24585
通过率: 暂无数据
审稿周期: 暂无数据
版面费用: 暂无数据
国人发稿量: 50
投稿须知/期刊简介:
The Journal of Pharmaceutical Sciences will publish original research papers original research notes invited topical reviews (including Minireviews) and editorial commentary and news. The area of focus shall be concepts in basic pharmaceutical science and such topics as chemical processing of pharmaceuticals including crystallization lyophilization chemical stability of drugs pharmacokinetics biopharmaceutics pharmacodynamics pro-drug developments metabolic disposition of bioactive agents dosage form design protein-peptide chemistry and biotechnology specifically as these relate to pharmaceutical technology and targeted drug delivery.
期刊描述简介:
The Journal of Pharmaceutical Sciences will publish original research papers original research notes invited topical reviews (including Minireviews) and editorial commentary and news. The area of focus shall be concepts in basic pharmaceutical science and such topics as chemical processing of pharmaceuticals including crystallization lyophilization chemical stability of drugs pharmacokinetics biopharmaceutics pharmacodynamics pro-drug developments metabolic disposition of bioactive agents dosage form design protein-peptide chemistry and biotechnology specifically as these relate to pharmaceutical technology and targeted drug delivery.
-
In vitro model of reconstructed human corneal epithelium for the evaluation of ocular surface desiccation and protection with vitamin A enriched ophthalmic ointment.
The aim of this study was to evaluate the efficacy of a paraffin ointment enriched with vitamin A in the protection against severe desiccation using 2D and 3D corneal epithelial in vitro models. We used immortalized human corneal epithelial cell cultures to evaluate the efficacy of four compounds -a paraffin ointment enriched with vitamin A (vA-PFF) and its vehicle; an aqueous gel containing hydroxypropyl guar (HPG); and an aqueous gel containing sodium carboxymethylcellulose (CMC)- to preserve cell viability in an in vitro model of desiccation. WST-1 and Live/Dead assays were used to study cell viability. Protection against cell damage was evaluated using a tridimensional reconstructed human corneal epithelial stem cell model (QobuR-RhCE). Compared to CMC, the paraffin ointment produced a significant prosurvival effect and it was similar to hydroxypropyl guar (HPG). The effect of vA-PFF in the protection against cell damage in QobuR-RhCE was significantly higher than CMC and HPG. Our results suggested that reconstructed 3D human corneal epithelia are sensitive tools to evaluate the efficacy of topical formulations against chemical damage and severe desiccation, indicating that would be an alternative method to animal experimentation, valid to use in ocular drug screening. vA-PFF caused no toxicity to cells in culture and was effective against extreme desiccation and cell damage in vitro 2 D and 3D models.
被引量：- 发表：1970
-
Engineering of Layer-by-layer Acetate-coated Paclitaxel Loaded Poly(lactide-co-glycolide) Acid Nanoparticles for Prostate Cancer Therapy- in vitro.
被引量：- 发表：1970
-
Population pharmacokinetics and dosing simulations of meropenem in septic critically ill patients with complicated intra-abdominal infection or pneumonia.
被引量：- 发表：1970
-
Determination of Solid-State Acidity of Lyophilized Trehalose Containing Citrate, Phosphate, and Histidine Buffers Using UV/VIS Diffuse Reflectance and Solid-State NMR Spectroscopy.
被引量：- 发表：1970
-
Quality risk management and data integrity in R&D laboratories supporting CMC lifecycle of biological products.
被引量：- 发表：1970
