自引率: 1%
被引量: 48353
通过率: 暂无数据
审稿周期: 1.06
版面费用: 暂无数据
国人发稿量: 25
投稿须知/期刊简介:
FEBS Letters is one of the world''''''''s leading journals in biochemistry and molecular biology and is renowned both for its quality of content and speed of production. Bringing together the most important developments in the molecular biosciences, FEBS Letters provides an international forum for Minireviews, Research Letters and Hypotheses that merit urgent publication.FEBS Letters offers:Fast turnaround. Papers that do not qualify for review are returned to the author within 2 days from submission. Average time to first decision is 2.3 weeks. Accepted papers appear online within 5 days. The print version of the article is published in 3 to 5 weeks after acceptance. Articles in Press are included in PubMed.Fair and competent peer review. All FEBS Letters articles are peer reviewed by highly qualified scientists. The journal’s Reviewer database includes over 30000 scientists from all over the world. Special attention is paid to conflicts of interest.Edited by specialists in the field. Manuscripts are directly handled by Academic Editors, who are highly ranked scientists that regularly publish in a related field.Transparency. Manuscripts can be easily tracked throughout the review process. Authors are welcome to openly discuss problems with the Editor. Editor names are published on the article front page. Author contributions are mentioned on the published article.Easy-to-use online submission system. The journal offers a user-friendly online submission system, which allows authors to submit their manuscript as a single file for the initial peer review process.Free access for all reviews. All FEBS Letters Reviews, Hypotheses and Special Issues are immediately made freely available, at no extra cost for the authors. In addition, a small selection of high quality Research Letters are also made freely accessible as a means to promote good research.Fast track option. FEBS Letters offers expedited handling of manuscripts that have been rejected from high-level journals with reviews. A final decision is reached within a week from submission. Open Access options. FEBS Letters is a hybrid open access journal and offers authors the option to sponsor non- subscriber access to their articles on Wiley Online Library.Longevity The cited half-life of FEBS Letters articles is >10 years.No page charges and free color figures.FEBS is not for profit. FEBS is one of the largest not-for-profit organizations in life sciences today. The income generated by FEBS Letters is reinvested in science to support fellowships, advanced courses and the annual FEBS Congress.<br clear="none" style="color: rgb(66, 66, 66); font-family: " open="" sans",="" arial,="" helvetica,="" "lucida="" sans="" unicode",="" sans-serif;="" font-size:="" 13px;="" user-select:="" text="" !important;"="">Aims and Scope<br clear="none" style="color: rgb(66, 66, 66); font-family: " open="" sans",="" arial,="" helvetica,="" "lucida="" sans="" unicode",="" sans-serif;="" font-size:="" 13px;="" user-select:="" text="" !important;"="">The subject area of FEBS Letters covers all the basic molecular biosciences inherent to microbes, plants and animals in health and disease. To enhance visibility of published articles in different fields, the journal is now subdivided into the following sections:Bioenergetics; Biophysics; Cell fate determination (cell cycle, cell differentiation, cell death); Chemical Biology; Computational Biology (genomics, proteomics, bioinformatics); Cytoskeleton; Development; Enzymology; Evolution; Genome organization and stability; Glycobiology; Immunology; Membrane Biology (membrane trafficking, vesicles, organelles); Metabolism; Microbiology; Molecular basis of disease; Neuroscience; Plant Biology; Protein Chemistry; Protein Homeostasis; Redox Biology; Regulation of gene expression; RNA Biology; Signal Transduction; Structural Biology; Synthetic Biology; Systems Biology; and Virology.Research Letters should be short but complete and essentially final reports providing molecular mechanistic insight. Methodological papers are considered for publication only when they are truly novel and significant, and interesting to a broad readership.
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Mutational analysis of GstI protein, a glutamine synthetase translational inhibitor of Rhizobium leguminosarum.
The small GstI protein (63 amino acids) of Rhizobium leguminosarum inhibits the expression of the glnII (glutamine synthetase II) gene, thus reducing the bacterial ability to assimilate ammonium. In order to identify the residues essential for its inhibitory activity, all the 53 non-alanine amino acid residues of GstI were individually mutated into alanine. Based on their capacity to inhibit glnII expression (in two genetic backgrounds) three groups of mutants were identified. The first group displayed an inhibitory activity similar to the wild-type; the second and the third ones showed partial and total loss of inhibitory activity, respectively. Several mutations of the latter group concerned residues conserved in two related sequences from Sinorhizobium meliloti and Agrobacterium tumefaciens. Additionally, we performed experiments to exclude a GstI-mediated mechanism of glutamine synthetase II inhibition/degradation. Finally, the protein was over expressed in Escherichia coli, purified and characterised.
被引量：2 发表：2004
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The fas locus of the phytopathogen Rhodococcus fascians affects mitosis of tobacco BY-2 cells.
:The effect of Rhodococcus fascians, the causal agent of leafy gall disease, on the mitotic behavior of synchronized tobacco Bright Yellow-2 (BY-2) cells was investigated. Incubation of aphidicolin-synchronized BY-2 cells with R. fascians cells specifically resulted in a broader mitotic index peak, an effect that was linked to an intact and expressed fas virulence locus. The obtained results pointed towards an effect of R. fascians on the prophase of mitosis. The relevance of these results to the virulence of the bacterium is discussed.
被引量：- 发表：2001
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Homing markers for atherosclerosis: applications for drug delivery, gene delivery and vascular imaging.
:Endothelial dysfunction plays a major role in the pathogenesis of atherosclerosis. Pro-inflammatory cytokines such as interleukin-1 beta and tumour necrosis factor alpha activate endothelial cells changing their resting phenotype to become pro-adhesive, pro-thrombotic and pro-atherogenic. Phage display in vivo biopanning has been used to identify peptide sequences that home to diseased regions of the vessel wall in low density lipoprotein receptor (LDLr) knockout mice. In LDLr knockout mice, peptide sequence determinants exhibiting organ specificity have been isolated. These sequences have applications for gene delivery, drug delivery and for improving contrast agents for vascular imaging.
被引量：- 发表：2001
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Expression levels of RGS7 and RGS4 proteins determine the mode of regulation of the G protein-activated K(+) channel and control regulation of RGS7 by G beta 5.
:Regulators of G protein signaling RGS4 and RGS7 accelerate the kinetics of K(+) channels (GIRKs) in the Xenopus oocyte system. Here, via quantitative analysis of RGS expression, we reveal biphasic effects of RGSs on GIRK regulation. At low concentrations, RGS4 inhibited basal GIRK activity, but stimulated it at high concentrations. RGS7, which is associated with the G protein subunit G beta 5, is regulated by G beta 5 by two distinct mechanisms. First, G beta 5 augments RGS7 activity, and second, it increases its expression. These dual effects resolve previous controversies regarding RGS4 and RGS7 function and indicate that they modulate signaling by mechanisms supplementary to their GTPase-activating protein activity.
被引量：- 发表：2001
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Retinol binding protein expression is induced in HepG2 cells by zinc deficiency.
:Zinc (Zn) deficiency is often associated with low plasma vitamin A (retinol) concentrations. It has been suggested that the reduction in plasma retinol is secondary to reduced liver retinol binding protein (RBP) synthesis. In the present study, RBP expression was determined in HepG2 cells cultured in either Zn adequate media or chelated media containing varying concentrations of Zn. Levels of RBP mRNA increased in a time- and Zn concentration-dependent manner such that 0.5 microM Zn-treated cells exhibited a >7.5-fold increase while cells treated with 15 microM Zn were increased 2.9-fold at 72 h compared to controls. RBP protein also progressively increased by 72 h to levels >8-fold and 3-fold higher than controls, in 0.5 microM and 15 microM Zn-treated cells, respectively. The increase in RBP occurred without any change in DNA concentration between groups through 72 h. The Zn deficiency-induced elevations in RBP transcript levels could be reversed within 24-48 h of repletion in Zn adequate media. Thus, the reductions in plasma retinol observed in Zn deficiency are in part a direct consequence of the deficiency.
被引量：1 发表：2001
