自引率: 11.9%
被引量: 41245
通过率: 暂无数据
审稿周期: 1.67
版面费用: 暂无数据
国人发稿量: 12
投稿须知/期刊简介:
The American Journal of Obstetrics and Gynecology, “The Gray Journal”, covers the full spectrum of Obstetrics and Gynecology. The aim of the Journal is to publish original research (clinical and translational), reviews, opinions, video clips, podcasts and interviews that will have an impact on the understanding of health and disease and that has the potential to change the practice of women''s health care. An important focus is the diagnosis, treatment, prediction and prevention of obstetrical and gynecological disorders. The Journal also publishes work on the biology of reproduction, and content which provides insight into the physiology and mechanisms of obstetrical and gynecological diseases. <br style="">Benefits to authors<br style="">We also provide many author benefits, such as free PDFs, a liberal copyright policy, special discounts on Elsevier publications and much more. Please click here for more information on our author services. <br style=""><br style="">Please see our Guide for Authors for information on article submission. If you require any further information or help, please visit our Support Center
期刊描述简介:
The American Journal of Obstetrics and Gynecology, “The Gray Journal”, covers the full spectrum of Obstetrics and Gynecology. The aim of the Journal is to publish original research (clinical and translational), reviews, opinions, video clips, podcasts and interviews that will have an impact on the understanding of health and disease and that has the potential to change the practice of women's health care. An important focus is the diagnosis, treatment, prediction and prevention of obstetrical and gynecological disorders. The Journal also publishes work on the biology of reproduction, and content which provides insight into the physiology and mechanisms of obstetrical and gynecological diseases.
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Clinical outcomes following preimplantation genetic testing for monogenic conditions, a systematic review of observational studies.
We aimed to report a summary of clinical outcomes following preimplantation genetic testing for monogenic conditions, by performing a systematic review of published literature on clinical pregnancy and live birth rates following preimplantation genetic testing due to a monogenic indication. Additionally, we aimed to undertake a subgroup analysis of clinical outcomes of concurrent monogenic and aneuploidy screening. Three electronic databases (MEDLINE, EMBASE and PubMed) were searched from inception to May 2024. STUDY ELIGIBILITY CRITERIA (STUDY DESIGN, POPULATIONS, AND INTERVENTIONS [IF APPLICABLE]): Quantitative data audits, observational studies and case series reporting clinical outcomes for individuals undergoing preimplantation genetic testing for a monogenic indication were included. Only studies using blastocyst biopsies with polymerase chain reaction-based or genome-wide haplotyping methods for molecular analysis were eligible to reflect current laboratory practice. Quality assessment was performed following data extraction using an adaptation of the Joanna Briggs critical appraisal tool for case series. Results were extracted, and pooled mean clinical pregnancy rates and birth rates were calculated with 95% confidence intervals. We compared outcomes between those with and without concurrent PGT-A. Our search identified 1372 publications; 51 were eligible for inclusion. Pooled data on 5305 cycles and 5229 embryo transfers yielded 1806 clinical pregnancies and 1577 births. This translated to clinical pregnancy and birth rates of 34.0% [95%CI: 32.8-35.3%] and 29.7% [95%CI: 28.5-31.0%] per cycle and 24.8% [95%CI: 23.6-26.0%] and 21.7% [95%CI: 20.8-23.1%] per embryo transfer. In studies with concurrent aneuploidy screening, clinical pregnancy and birth rates were 43.3% [95%CI: 40.2-46.5%] and 37.6% [95%CI: 34.6-40.8%] per cycle and 37.0% [95%CI: 33.9-40.3%] and 31.8% [95%CI: 28.8-35.0%] per embryo transfer. Studies without aneuploidy screening reported clinical pregnancy and birth rates of 32.5% [95%CI: 31.0-34.1%] and 28.1% [95%CI: 26.6-29.7%] per cycle and 21.2% [95%CI: 19.8-22.6%] and 18.6% [95%CI: 17.3-20.0%] per embryo transfer. This systematic review reveals promising clinical outcome figures for this indication group. Additionally, synthesizing the published scientific literature on clinical outcomes from preimplantation genetic testing for monogenic conditions provides a rigorous, non-commercial evidence base for counselling.
被引量：- 发表：1970
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Efficacy of pharmacologic hemorrhage prophylactics in second-trimester abortions: a systematic review.
被引量：- 发表：1970
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Pregnancy: an underutilized window of opportunity for genetic cancer risk assessment.
被引量：- 发表：1970
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Advancing maternal and neonatal health: a comprehensive approach to methamphetamine use in pregnancy.
被引量：- 发表：1970
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Hysteroscopic myomectomy and the risk for placenta accreta spectrum: implications for subfertile patients and underlying pathophysiology.
被引量：- 发表：1970
