自引率: 3.9%
被引量: 21908
通过率: 暂无数据
审稿周期: 1
版面费用: 暂无数据
国人发稿量: 4
投稿须知/期刊简介:
Published by Springer. ISSN (printed): 0001-6322. ISSN (electronic): 1432-0533.<br> Organ of the Research Group for Neuropathology the Research Group for Comparative Neuropathology the Rese
期刊描述简介:
Acta Neuropathologica´s mission is to publish the best articles on pathology and pathogenesis of neurological disease. The journal focuses on structural and molecular neuropathology using human tissue, animal models and in vitro systems. The journal publishes Original Papers, Review Articles, Case Reports and Scientific Correspondence.
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Regulated cell death in neurodegeneration: pathways and therapeutic horizons.
被引量：- 发表：1970
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Tau accumulation is cleared by the induced expression of VCP via autophagy.
被引量：- 发表：1970
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TDP-43 regulates LC3ylation in neural tissue through ATG4B cryptic splicing inhibition.
被引量：- 发表：1970
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Association of in vivo retention of [(18)f] flortaucipir pet with tau neuropathology in corresponding brain regions.
被引量：- 发表：1970
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HOXD12 defines an age-related aggressive subtype of oligodendroglioma.
Oligodendroglioma, IDH-mutant and 1p/19q-codeleted has highly variable outcomes that are strongly influenced by patient age. The distribution of oligodendroglioma age is non-Gaussian and reportedly bimodal, which motivated our investigation of age-associated molecular alterations that may drive poorer outcomes. We found that elevated HOXD12 expression was associated with both older patient age and shorter survival in the TCGA (FDR < 0.01, FDR = 1e-5) and the CGGA (p = 0.03, p < 1e-3). HOXD12 gene body hypermethylation was associated with older age, higher WHO grade, and shorter survival in the TCGA (p < 1e-6, p < 0.001, p < 1e-3) and with older age and higher WHO grade in Capper et al. (p < 0.002, p = 0.014). In the TCGA, HOXD12 gene body hypermethylation and elevated expression were independently prognostic of NOTCH1 and PIK3CA mutations, loss of 15q, MYC activation, and standard histopathological features. Single-nucleus RNA and ATAC sequencing data showed that HOXD12 activity was elevated in neoplastic tissue, particularly within cycling and OPC-like cells, and was associated with a stem-like phenotype. A pan-HOX DNA methylation analysis revealed an age and survival-associated HOX-high signature that was tightly associated with HOXD12 gene body methylation. Overall, HOXD12 expression and gene body hypermethylation were associated with an older, atypically aggressive subtype of oligodendroglioma.
被引量：- 发表：1970
